关键词: 蛋白激酶 C, 酶抑制剂, 胰蛋白酶抑制剂, 蛋白激酶抑制剂, 肿瘤, 综述

Abstract: Abstract: Protein kinase C (PKC) is a group of phospholipid-dependent serine/threonine protein kinases, which togeth⁃ er with protein kinase A (PKA) and protein kinase G (PKG) constitute a superfamily of serine/threonine protein kinase AGC. PKC includes classic PKC, novel PKC, atypical PKC and some members of kinase associated with PKC (PRK). PKC is wide⁃ ly distributed in mammalian tissues and cells, which plays an important biological role in growth and metabolism, prolifera⁃ tion and differentiation of cells. A series of studies have demonstrated that variations of multiple cells, occurrence and devel⁃ opment of diseases are related to the abnormal expression of PKC. Therefore, designing and searching for efficient PKC inhib⁃ itors have very important implications for synthesis of many kinds of effective drugs and treatment of a variety of clinical dis⁃ eases including cancer, cardiovascular, and hypertension, et al. In recent years, the research on PKC inhibitors has become the focus of domestic and foreign research. A large number of literatures have reported many kinds of effective PKC inhibi⁃ tors, and analyzed their function site, mechanism, clinical trial data and so on. The discovery of these PKC inhibitors has im⁃ portant implications for structural analysis of PKC and the treatment of diseases. So in this paper, the efficient PKC inhibi⁃ tors are summarized.

Key words: protein kinase C, enzyme inhibitors, trypsin inhibitors, protein kinase inhibitors, neoplasms, review