Abstract: Objective To investigate the expression and clinical significance of transcriptional activator (STAT) 1 and matrix metalloproteinases (MMP)- 2 in pancreatic cancer (PC). Methods The expressions of STAT1 and MMP- 2 weredetected by S-P immunohistochemical methods in 115 PC patients and whose age, tumor size, lymph node metastasis, TNM stage, differentiation and survival time were also collected. Results STAT1 protein was high expressed in 52 cases and MMP-2 was high expressed in 56 cases, which were significantly related with different clinical stages, tumor differentiation and lymph node metastasis in patients with PC (P＜ 0.05). STAT1 expression was negatively correlated with MMP- 2 expression (rs = - 0.50, P＜ 0.01). Lymph node metastasis, high level of clinical stage, low expression of STAT1 showed reduced postoperative survival time in patients with PC. Conclusion The lower expression of STAT1 and higher expression of MMP-2 play an important role in the progression of PC. The expression of STAT1 has practical value in the evaluation of prognosis in patients with PC ．

Key words: pancreatic neoplasms, matrix metalloproteinase 2, immunohistochemistry, prognosis, STAT1