Abstract:  Objective To analyze the expression and significance of kinesin family member 23 (KIF23) in breast cancer based on databases mining. Methods In this study, the differential expression of KIF23 gene in breast cancer and normal tissues was compared using the Oncomine and GCBI databases, and then its expression level was overall analyzed. The relationship between KIF23 expression level and prognosis survival, including relapse-free survival (RFS), overall survival (OS), distant metastases-free survival (DMFS) and post-progression survival (PPS), in breast cancer patients were analyzed by the Kaplan-Meier Plotter database. Results It was discovered that KIF23 was more abundantly expressed in breast cancer and a total of 39 studies in the Oncomine database were involved in the expression level of KIF23 in breast cancer and normal tissues. The median rank of KIF23 gene was 900.0 in all differentially expressed genes of breast cancer (P＜0.05). The expression levels of KIF23 were higher in 23 invasive and 4 non-invasive samples of breast cancer, the median rank of differentially expressed genes was statistically significant (P＜0.05). KIF23 was highly expressed in breast cancer (587.27) compared with that of normal tissues (90.89) after integrated analysis (P＜0.05), which was also proved in the GCBI. In addition, Kaplan-Meier Plotter database analysis indicated that the high expression of KIF23 was closely associated with poor survival. Further analysis showed that the expression levels of survival indicators in ER (+) group were statistically significant. Conclusion KIF23 is highly expressed in breast cancer and is associated with poor prognosis in patients, which may be important for the diagnosis, treatment and prognosis assessment of breast cancer.

Key words: breast neoplasm, kinesin family member 23, databases, gene expression, prognosis