Abstract: Abstract：Objective To study the change trend of T-cell spot of Tuberculosis (T-SPOT.TB) in the effective process of early anti-tuberculosis treatment of tuberculosis. Methods Fifty newly diagnosed patients with active pulmonary tuberculosis who received regular anti-tuberculosis treatment in tuberculosis department of our hospital from June 2016 to February 2019 were selected as subjects of the study. The dynamic change trend of T-SPOT.TB results and the changes of body's response to tuberculosis specific antigen [early secreting antigen target-6 (ESAT-6), culture filtrate protein-10 (CFP- 10)] stimulation before and after anti-tuberculosis treatment (30 days, 1 month and 3 months) were analyzed. Results During the period of effective anti-tuberculosis treatment of three months, the results of T-SPOT.TB decreased gradually with the prolongation of treatment time, and the difference was statistically significant (P＜0.05). The changes of immune response to ESAT-6 and CFP-10 were consistent after treatment for three months. Conclusion T-SPOT.TB may be a good indicator for monitoring the efficacy of tuberculosis. The changes of body response to ESAT-6 and CFP-10 are consistent after anti-tuberculosis treatment (at the 3rd month).

Key words: pulmonary tuberculosis, T-SPOT.TB, result change, treatment monitoring