Abstract: Abstract：Objective To explore the effects of dexmedetomidine combined with sufentanil anesthesia on the analgesic
effect and immune function of patients with lung cancer resection. Methods A total of 120 patients with lung cancer who
were admitted to our hospital from July 2017 to July 2019 were randomly divided into single group and composite group, with
60 patients in each group. After surgical resection, the patient-controlled analgesia (PCIA) was performed by intravenous
infusion of sufentanil alone in the single anesthesia group and sufentanil combined with dexmedetomidine in the composite
anesthesia group. Visual analogue pain score (VAS) and comfort score (BCS) were performed at 1, 6, 12, 24 and 48 h after
the surgery to evaluate the analgesic effect in the two groups. In addition, the proportion of immune cells and the expression
levels of immune factors in the peripheral blood were measured before and at 12, 24, 48 h, 1 week and 2 weeks after surgery
in the two groups. Results (1) VAS and BCS scores were significantly lower in the composite group than those in the single
group (P＜0.05). (2) Compared with the same period in the single group, the proportions of NK cells, CD3+ T cells and CD4+/
CD8+ were significantly increased in the composite group at 12, 24 and 48 h after surgery (P＜0.05). The CD8+ cells were
significantly lower at 12, 24 and 48 h after surgery in the composite group (P＜0.05). IFN-γ contents were significantly
lower at 12, 24 h, 48 h and 1 week after surgery in the composite group than those of the single group (P＜0.05), while IL-10
levels were significantly higher than those of the single group (P＜0.05 or P＜0.01). There was no significant difference in
the incidence of postoperative complications between the two groups (P＞0.05). Conclusion Dexmedetomidine combined
with sufentanil PCIA has better analgesic effect and higher postoperative comfort in patients after radical operation. Most
importantly, the compound anesthesia can improve the immune function.

Key words: dexmedetomidine, sufentanil, analgesic effect, immune function, lung cancer resection, patient intravenous
controlled analgesia