Abstract: Objective　To study the relationship between gene polymorphism of TRPC3 and left ventricular hypertrophy(LVH) inpatients with essential hypertensive (EH). Methods　Genomic DNA was isolated from blood of 305 EH patients, including 205 male patients and 100 female patients. According to the left ventricular mass index (LVMI)，the patients were divided into simple hypertension group (normal group, n=224) and EH+LVH group (n=81). The differences in general data such as age and smoking history were analyzed between the two groups.The single nucleotide polymorphism (SNP) sites Rs2292232, Rs4995894 and Rs4292355 of TRPC3 gene were genotyped by Sequenom MassARRAY® SNP detection technology. Logistic regression analysis was used for analyzing factors affecting LVH inpatients. Results　(1) There were no significant differences in age, smoking history, drinking history, family history, urea, creatinine, fasting blood glucose, triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and 24-hour mean diastolic blood pressure (24 h DBP) between the two groups. The male proportion was lower in EH+LVH group than those of normal group. Values of 24 h DBP and body massindex (BMI) were higher in EH+LVH group than those of normal group (P＜0.05). (2) There were no significant differences in gene frequency and genotype frequency distribution of Rs4995894 and Rs4292355 between the 2 groups (P＞0.05), and there were significant differences in the frequency distribution of the TRPC3 gene SNP site Rs2292232 (P＜0.05). The distribution frequency of Rs2292232 point TT genotype was significantly higher in the EH + LVH group than that of normal control group (P＜0.05). (3) The Logistic regression analysis showed that woman (OR=0.332,95%CI:0.181-0.610，P＜0.05), higher 24-hour DBP (OR=1.035,95%CI:1.014-1.056,P＜0.05) and the TRPC3 gene SNP Rs2292232 TT genotype (OR=2.105，95%CI:1.109-3.995，P＜0.05) were independent risk factors for LVH in hypertensive patients. Conclusion　The Rs2292232 SNP of TRPC3 gene is risk factor for EH patients with LVH, and TT gene type is more likely to develop LVH.  

Key words: transient receptor potential channels, polymorphism, single nucleotide, gene frequency, essential hypertension；left ventricular hypertrophy；transient receptor potential-canonical 3 channels