Abstract: Objective To investigate clinical features and imaging manifestation of patients with the COVID-19 infection in Shijiazhuang. Methods A total of 21 patients with COVID-19 admitted in the fifth hospital in Shijiazhuang from January 21 to February 10, 2020 were selected as the research subjects. The demographic characteristics, clinical data, laboratory indexes and pulmonary imaging characteristics of patients were retrospectively analyzed. According to the age, the patients were divided into two groups: group<45 years old (n=13) and group≥45 years old (n=8). The differences in the above indicators were compared between the two groups. Results Of the 21 COVID-19 patients, 14 were male (66.7%) and 7 were female (33.3%). There were 7 families with clustered incidence (n=19). Clinical signs included fever in 15 cases (71.4%), cough in 9 cases (42.9%) and no clinical symptoms in 5 cases (23.8%). Results of laboratory examination showed that T lymphocyte subsets CD3＋ decreased in 8 cases (38.1%), CD4+ decreased in 12 cases (57.1%), CD8+ decreased in 6 cases (28.6%), leukocyte decreased in 2 cases (9.5%), neutrophil decreased in 2 cases (9.5%), lymphocyte decreased in 5 cases (23.8%), and C-reactive protein (CPR) elevated in 10 cases（47.6%）. There were no significant differences in CD3+ , CD4+ , CD8+ , leukocyte count, neutrophil and lymphocyte and CRP levels between the two age groups (P＞0.05). Of the 21 patients with COVID-19, 3 cases showed no abnormalities in CT examination. The first imaging examination before admission included chest X-rays in 11 cases and lung CT imaging in 10 cases. There were 6 cases of false negative in chest X-ray examination (missed diagnosis rate 54.5%). The lung CT examination showed positive in all 11 cases. Conclusion The COVID-19 infected patients in Shijiazhuang are mainly family-clustered cases. The T lymphocyte subtypes decrease significantly. The early chest X-ray imaging is easily misdiagnosed for COVID-19 infection

Key words: coronavirus, pneumonia, viral, COVID-19, SARS-CoV-2, T-lymphocyte subsets, Shijiazhuang, imaging features