Abstract: Objective　To explore the feasibility and safety of complete laparoscopy bilateral thyroid lobectomy through subclavian approach without inflation. Methods The clinical data of 43 patients with bilateral total thyroidectomy in the first ward of the First Affiliated Hospital of Bengbu Medical College from December 2019 to April 2020 were retrospectively analyzed. Among them, 13 cases underwent complete laparoscopy bilateral thyroid lobectomy (laparoscopy group) without gas-filled subclavian approach, and 30 cases underwent traditional open surgery (open group). The operation time, intraoperative blood loss, postoperative drainage volume, parathormone (PTH) on the first postoperative day, postoperative hospital stay, surgical complications and cosmetic satisfaction were recorded in the two groups. Results　The age of the laparoscopy group (46.2±10.1) was less than that of the open group (57.4±7.9, P＜0.05). There were no significant differences in gender ratio, tumor diameter and tumor nature between two groups (P＞0.05). The operation time [(124.2±15.8) min vs. (92.9±9.7) min] and the amount of drainage fluid [(147.1±42.9) mL vs. (103.7±16.5) mL] were higher in the laparoscopy group than those in the open group (P＜0.05). The intraoperative blood loss [(26.1±8.5) mL vs. (37.0±10.9) mL] was less in the laparoscopy group than that of the open group. There were no significant differences in hospitalization time and postoperative PTH at first day of operation between the two groups (P＞0.05). The postoperative cosmetic satisfaction was higher in the endoscopic group than that of the open group (P＜0.05). Conclusion　The complete laparoscopy bilateral thyroid lobectomy without air-filled subclavian approach is safe, feasible and has a better cosmetic effect, which is worthy of promotion.

Key words: thyroidectomy, endoscopes, without gas-fill, subclavian approach