Tianjin Medical Journal

Tianjin Medical Journal ›› 2021, Vol. 49 ›› Issue (6): 617-621.doi: 10.11958/20210036

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The significance of HA, ColⅣ, LN and PⅢNP-P in the evaluation of connective tissue disease with interstitial lung disease

LIU Xiao-min, SUN Hui-ying, WANG Yong-fu, LU Fu-ai #br#   

  1. 1 Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou 014010, China; 2 Department of
    Rheumatology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology
  • Received:2021-01-11 Revised:2021-02-10 Published:2021-06-15 Online:2021-06-15

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Abstract: ObjectiveTo explore the significance of the serum changes of hyaluronic acid (HA), Ⅳ type collagen, (Col Ⅳ),
laminin (LN) and type Ⅲ before pre-collagen n-terminal peptide (PⅢNP-P) in connective tissue diseases-interstitial lung
disease (CTD-ILD). MethodsA total of 157 patients diagnosed as connective tissue disease were selected, including 87
patients with the lung high-resolution CT (HRCT) diagnosed with ILD (CTD-ILD group) and 70 patients without combined
ILD (CTD-non-ILD group). The clinical data and serum test results were collected in 2 groups of patients. The pulmonary
function test, blood gas analysis and lung HRCT, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), HA, Col Ⅳ,
LN, PⅢNP-P and other indicators were also collected. The clinical significance of HA, Col Ⅳ, LN and PⅢNP-P in CTD-ILD
was analyzed. Results The serum levels of HA and Col Ⅳ were significantly increased in CTD-ILD group compared with
those of the CTD-non ILD group (P＜0.05). There were no significant differences in serum ESR, CRP, PⅢNP-P and LN
between the 2 groups of patients. The serum level of HA was positively correlated with ESR, CRP, alveolar inflammation
score and clinical-radio-physiological score in CTD-ILD group (rs= 0.230, 0.254, 0.497 and 0.267, P＜0.05), and
negatively correlated with arterial oxygen partial pressure [p（O2）] (rs=-0.318, P＜0.01). The serum level of Col Ⅳ was
positively correlated with alveolar inflammation score in CTD-ILD group (rs=0.212, P＜0.05), and negatively correlated
with p(O2) (rs=-0.327, P＜0.01). ConclusionThe serum levels of HA and Col Ⅳ are closely related to the degree of lung
inflammation of CTD - ILD, suggesting its predictive value for CTD-ILD. HA is closely associated with the condition of
CTD-ILD activity, which can be used as an indicator to reflect the disease activity of CTD-ILD.

Key words: connective tissue diseases, lung diseases, interstitial, hyaluronic acid, collagen type Ⅳ , laminin, extracellular matrix, collagen type Ⅲ before n-terminal peptide, clinical radiographic physiologic score