Abstract: Objective To compare the effect of centrifugal pump and roller pump on platelet in Stanford A-type aortic dissection under cardiopulmonary bypass (CPB). Methods A total of 40 patients who planned to undergo a surgery were enrolled, and they were divided into the centrifugal pump group (n=20) and the roller pump group (n=20) according to the random number table. Data of CPB time, aortic cross-clamp time, circulatory arrest time, blood consumption, coagulation function, liver and kidney function, blood routine, postoperative chest drainage, mechanical ventilation time, ICU (intensive care unit) length of stay, length of hospital stay, and complications were recorded in the two groups. Platelet α -granule membrane protein 140 (GMP-140) and platelet factor 4 (PF4) concentration and platelet count were detected after induction of anesthesia (T1), 0.5 h after fish sperm neutralization (T2), 4 h in ICU (T3), 24 h in ICU (T4), and 48 h in ICU (T5). Results There were no significant differences in baseline data and intraoperative indicators (CPB time, aortic cross-clamp time, circulatory arrest time, blood consumption, bleeding volume) between the two groups (P＞0.05). At T2-T4, compared with the roller pump group, platelet count was increased, and the concentration of PF4 and GMP140 decreased in the centrifugal pump. At 4 h and 24 h, the chest drainage and blood consumption were significantly less in the centrifugal pump group than those in the roller pump group (P＜0.05). There were no significant differences in mechanical ventilation time, ICU stay time, length of hospital stay, 48 h chest drainage and complications between the two groups (P＞0.05). Conclusion In the operation of Stanford type A aortic dissection, the centrifugal pump can reduce platelet activation and consumption, and reduce postoperative bleeding and blood consumption.

Key words: aneurysm, dissecting, extracorporeal circulation, platelet count, roller pump, centrifugal pump