Clinical observation of preoperative intravenous administration of esketamine on sedation and induction compliance in preschool children

doi:10.11958/20212781

Abstract

Abstract:

Objective To explore the effect of preoperative intravenous administration of different doses of esketamine on sedation and anesthesia induction compliance in preschool children. Methods A total of 90 children scheduled for laparoscopic high ligation of hernia under general anesthesia were allocated, aged 1 to 6 years. The children were divided into the S₁ group, the S₂ group and the S₃ group (according to different intravenous doses of esketamine 0.6 mg/kg, 0.8 mg/kg and 1.0 mg/kg respectively) by random number table method, with 30 patients in each group. The Ramsay sedation score of children were recorded before medication (T₀), separating with parents 1 min after medication (T₁) and anesthesia induction (T₂). Induction Compliance Checklist (ICC) score and heart rate were also recorded. The adverse events during sedation and after recovery, and the recovery time were recorded. Results At T₁ and T₂, the Ramsay sedation score was better in the S₂ group and the S₃ group than that of the S₁group (P<0.05), and the Ramsay score of the S₃ group was higher than that of the S₂ group at T₂(P<0.05). The ICC score was lower in the S₃ group than that of the S₁group and the S₂ group (P<0.05). There was no significant difference in ICC score between the S₁group and the S₂ group (P>0.05). There were significant differences in ICC grades between the three groups (P<0.01). The proportion of children with perfect induction cooperation (ICC=0) was significantly higher in the S₃ group than that in the S₁ group and the S₂ group, and the proportion of children with poor induction cooperation (ICC=4-10) was significantly lower in the S₃ group than that in the S₁ group and the S₂ group (P<0.05). There were no significant differences in the incidence of adverse events and recovery time between the three groups (P>0.05). Conclusion Preoperative intravenous administration of esketamine 0.8 mg/kg and 1.0 mg/kg can improve the sedation effect of preschool children, but the sedation effect and induction compliance is superior with 1.0 mg/kg anesthesia induction.

Key words: Ketamine, injections,intravenous, deep sedation, child,preschool, Esketamine, induction compliance

CLC Number:

R726.14

Figures/Tables 5

References 12

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组别	年龄（岁）	性别（男/女）	体质量（kg）	手术时间（min）
S₁组	2.96±1.78	22/8	13.77±4.00	48.37±6.57
S₂组	2.30±1.01	23/7	13.12±2.88	47.50±5.88
S₃组	2.50±1.05	20/10	14.02±2.97	49.13±6.42
F或χ²	1.952	0.775	0.592	0.505

组别	年龄（岁）	性别（男/女）	体质量（kg）	手术时间（min）
S₁组	2.96±1.78	22/8	13.77±4.00	48.37±6.57
S₂组	2.30±1.01	23/7	13.12±2.88	47.50±5.88
S₃组	2.50±1.05	20/10	14.02±2.97	49.13±6.42
F或χ²	1.952	0.775	0.592	0.505

组别	T₀	T₁	T₂
S₁组	1.57±0.50	1.83±0.59	1.60±0.72
S₂组	1.43±0.50	4.57±0.82^a	3.20±1.79^a
S₃组	1.60±0.56	4.90±1.00^a	4.67±1.15^ab
F	0.848	126.890^＊＊	41.865^＊＊

组别	T₀	T₁	T₂
S₁组	1.57±0.50	1.83±0.59	1.60±0.72
S₂组	1.43±0.50	4.57±0.82^a	3.20±1.79^a
S₃组	1.60±0.56	4.90±1.00^a	4.67±1.15^ab
F	0.848	126.890^＊＊	41.865^＊＊

组别	ICC评分	ICC评分
组别	ICC评分	0	1~3	4~10
S₁组	3.83±3.26	5（16.7）	13（43.3）	12（40.0）
S₂组	2.63±3.00	14（46.7）	4（13.3）	12（40.0）
S₃组	0.90±2.02^ab	23（76.7）	3（10.0）	4（13.3）
χ²	8.252^＊＊		25.243^＊＊