The relationship between changes of the macular ganglion cell-inner plexiform layer (GCIPL) thickness of the affected eye in patients with unilateral wet age-related macular degeneration and serum interleukin-8 level

doi:10.11958/20220889

Abstract

Abstract:

Objective To investigate changes of macular ganglion cell-inner plexiform layer (GCIPL) thickness of the affected eye in patients with unilateral wet age-related macular degeneration (wetAMD) and its relationship with serum interleukin-8 (IL-8) level. Methods A total of 120 patients with unilateral wetAMD were selected as the wetAMD group. According to the test results of fluorescein fundus angiography and indocyanine green angiography, patients were divided into the unilateral typical choroidal neovascularization (tCNV) group (45 cases) and the unilateral polypoid choroidal vasculopathy (PCV) group (75 cases). Seventy-five peoples (75 eyes) with normal ophthalmic examination in clinic physical check-up were enrolled as the normal control group. The general data were collected in the three groups. The GCIPL thickness parameters of studied eyes and the serum level of IL-8 were also detected. The above indicators were compared between the three groups. The relationship between GCIPL thickness, serum IL-8 level and wetAMD was analyzed, and the diagnostic value of GCIPL thickness was also analyzed. Results The proportion of smoking, proportion of diabetes mellitus and serum IL-8 level were significantly higher in the wetAMD group than those in the control group, while each measured value of GCIPL thicknesses in eyes with wetAMD was significantly lower than those in eyes of normal control group (P<0.05). The age, smoking rate, proportion of diabetes mellitus and serum IL-8 level were significantly higher in the tCNV group than those in the PCV group, while each measured value of GCIPL thicknesses in eyes with tCNV was significantly lower than that in the PCV eyes (P<0.05). Each measured value of GCIPL thicknesses in the affected eyes in patients with wetAMD was negatively correlated with serum IL-8 level (P<0.05). Multivariate Logistic regression analysis showed that smoking, diabetes mellitus, the decreased value of average GCIPL thickness and the elevated serum level of IL-8 were risk factors of wetAMD, and diabetes mellitus, the decreased value of average GCIPL thickness and the elevated serum level of IL-8 were risk factors of tCNV in patients with wetAMD (P<0.05). The area under the receiver operating characteristic curve (AUC) of the average GCIPL thickness in the diagnosis of wetAMD was 0.775 (95%CI: 0.710-0.832). When the cut-off value was 75.60 μm, the sensitivity was 63.33% and the specificity was 81.33%. The AUC of the average GCIPL thickness in the diagnosis of tCNV was 0.765 (95%CI: 0.678-0.837). When the cut-off value was 70.20 μm, the sensitivity was 64.44%, and the specificity was 82.62%. Conclusion The GCIPL thickness of the affected eye in patients with unilateral wetAMD is abnormally decreased, which is related to the increased serum level of IL-8, and the GCIPL thickness has certain auxiliary value for the diagnosis of wetAMD and tCNV.

Key words: wet macular degeneration, tomography, optical coherence, retinal ganglion cells, interleukin-8, choroidal neovascularization, polypoidal choroidal vasculopathy, ganglion cell-inner plexiform layer

CLC Number:

R774.5

Figures/Tables 8

References 20

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组别	n	性别（男/女）	年龄（岁）	吸烟	饮酒	高血压	糖尿病	冠心病	高脂血症	脑血管疾病	IL-8（μg/L）
对照组	75	42/33	70.65±7.45	11（14.67）	14（18.67）	17（22.67）	7（9.33）	7（9.33）	19（25.33）	13（17.33）	13.32（10.42，16.79）
wetAMD组	120	68/52	69.83±8.25	42（35.00）	29（24.17）	35（29.17）	34（28.33）	17（14.17）	44（36.67）	23（19.17）	17.01（15.73，20.70）
χ²、t或Z		0.008	0.861	9.641^＊＊	0.812	0.997	10.034^＊＊	0.999	2.711	0.103	5.660^＊＊

组别	n	性别（男/女）	年龄（岁）	吸烟	饮酒	高血压	糖尿病	冠心病	高脂血症	脑血管疾病	IL-8（μg/L）
对照组	75	42/33	70.65±7.45	11（14.67）	14（18.67）	17（22.67）	7（9.33）	7（9.33）	19（25.33）	13（17.33）	13.32（10.42，16.79）
wetAMD组	120	68/52	69.83±8.25	42（35.00）	29（24.17）	35（29.17）	34（28.33）	17（14.17）	44（36.67）	23（19.17）	17.01（15.73，20.70）
χ²、t或Z		0.008	0.861	9.641^＊＊	0.812	0.997	10.034^＊＊	0.999	2.711	0.103	5.660^＊＊

组别	n	平均	最小	上方	鼻上方	颞上方	下方	鼻下方	颞下方
对照组	75	80.95±6.42	76.83±8.18	80.80±7.68	83.52±8.48	79.92±5.87	79.00±7.05	80.69±7.70	81.95±6.63
wetAMD组	120	73.73±6.73	69.18±10.14	73.37±7.69	75.07±7.20	73.53±7.71	71.84±7.08	72.78±7.60	74.60±7.17
t		7.416^＊＊	5.504^＊＊	6.567^＊＊	7.433^＊＊	6.146^＊＊	6.884^＊＊	7.042^＊＊	7.168^＊＊

组别	n	平均	最小	上方	鼻上方	颞上方	下方	鼻下方	颞下方
对照组	75	80.95±6.42	76.83±8.18	80.80±7.68	83.52±8.48	79.92±5.87	79.00±7.05	80.69±7.70	81.95±6.63
wetAMD组	120	73.73±6.73	69.18±10.14	73.37±7.69	75.07±7.20	73.53±7.71	71.84±7.08	72.78±7.60	74.60±7.17
t		7.416^＊＊	5.504^＊＊	6.567^＊＊	7.433^＊＊	6.146^＊＊	6.884^＊＊	7.042^＊＊	7.168^＊＊

组别	n	性别（男/女）	年龄（岁）	吸烟	饮酒	高血压	糖尿病	冠心病	高脂血症	脑血管疾病	IL-8（μg/L）
PCV组	75	47/28	68.39±7.73	21（28.00）	17（22.67）	21（28.00）	16（21.33）	10（13.33）	28（37.33）	14（18.67）	16.41（15.12，18.25）
tCNV组	45	21/24	72.22±8.63	21（46.67）	12（26.67）	14（31.11）	18（40.00）	7（15.56）	16（35.56）	9（20.00）	19.45（16.70，24.26）
χ²、t或Z		2.932	2.519^＊	4.308^＊	0.246	0.132	4.826^＊	0.114	0.038	0.032	4.475^＊＊