Research progress on the role and mechanism of exosomal circRNA in gastric cancer

doi:10.11958/20240059

Abstract

Abstract:

Gastric cancer (GC) is one of the most common and high mortality tumors in the world, and the clinical staging during diagnosis is closely related to the prognosis of patients. Therefore, finding sensitive diagnostic biomarkers to improve the early diagnosis rate has become an urgent issue. Exosomes are nanoscale extracellular vesicles secreted by various cells, which play an important role in cellular communication by transporting bioactive substances in tumor microenvironment (TME). CircRNA is a type of non-coding RNA with a specific structure. Because it is difficulty in degradation, it can be enriched in extracellular vesicles and participate in various pathophysiological processes mediated by it. Exo-circRNA can affect the proliferation, invasion, drug resistance and tissue metastasis of tumor cells, and has more significant diagnostic specificity than conventional diagnostic biomarkers in clinical practice. It may become a supplement to biomarker for the diagnosis and prognosis of GC. This article briefly introduces the characteristics, formation mechanism and role of extracellular vesicles and circRNA in GC. It discusses in detail the role of exo-circRNA in the occurrence and development of GC, and discusses their potential clinical application value and challenges in GC.

Key words: stomach neoplasms, exosome, RNA, circular, biomarkers

CLC Number:

R735.2

Figures/Tables 1

References 43

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名称	生物学功能	机制	表达水平
circ_0079439^[18]	增殖（-）、迁移（-）	未知	下调
circNFATC3^[23]	增殖（+）	结合IGF2BP3蛋白抑制其泛素化	上调
CM-248aa^[24]	增殖（-）、迁移（-）	靶向SET-PP2A蛋白抑制胃癌进展	下调
circ_0088300^[29]	增殖（+）	结合miR-1305调节JAK/STAT信号传导途径	上调
circSHKBP1^[30]	增殖（+）、迁移（+）、侵袭（+）、淋巴转移、血管生成	靶向miR-582-3p/HuR/VEGF轴	上调
circRanGAP1^[31]	增殖（+）、迁移（+）、侵袭（+）、肺转移	靶向miR-877-3p-VEGFA轴	上调
circUBE2Q2^[32]	腹膜转移	靶向miR-370-3p-STAT3轴	上调
circRELLl^[33]	增殖（-）、迁移（-）、侵袭（-）	结合miR-637、下调EPHB3蛋白激活自噬	下调
circNRIP1^[34]	转移（+）	靶向AKT/mTOR轴	上调
circ_0001789^[35]	增殖（+）、血管生成	靶向miR-140-3p/PAK2轴增加VEGF-A蛋白的表达	上调
circTMEM181^[36]	PD-1抗性	诱导巨噬细胞CD39蛋白表达增强	上调
circ_0008253^[37]	OXA抗性	未知	上调
circPRRXl^[38]	ADR抗性	靶向miR-3064-5p和PTPN14基因	上调
circ-LDLRAD3^[39]	DDP抗性、增殖（+）、侵袭（+）	靶向miR-58832-SOX5轴	上调
ciRs-133^[40]	促进脂肪细胞分化	激活miR-133-PRDM16轴	上调

名称	生物学功能	机制	表达水平
circ_0079439^[18]	增殖（-）、迁移（-）	未知	下调
circNFATC3^[23]	增殖（+）	结合IGF2BP3蛋白抑制其泛素化	上调
CM-248aa^[24]	增殖（-）、迁移（-）	靶向SET-PP2A蛋白抑制胃癌进展	下调
circ_0088300^[29]	增殖（+）	结合miR-1305调节JAK/STAT信号传导途径	上调
circSHKBP1^[30]	增殖（+）、迁移（+）、侵袭（+）、淋巴转移、血管生成	靶向miR-582-3p/HuR/VEGF轴	上调
circRanGAP1^[31]	增殖（+）、迁移（+）、侵袭（+）、肺转移	靶向miR-877-3p-VEGFA轴	上调
circUBE2Q2^[32]	腹膜转移	靶向miR-370-3p-STAT3轴	上调
circRELLl^[33]	增殖（-）、迁移（-）、侵袭（-）	结合miR-637、下调EPHB3蛋白激活自噬	下调
circNRIP1^[34]	转移（+）	靶向AKT/mTOR轴	上调
circ_0001789^[35]	增殖（+）、血管生成	靶向miR-140-3p/PAK2轴增加VEGF-A蛋白的表达	上调
circTMEM181^[36]	PD-1抗性	诱导巨噬细胞CD39蛋白表达增强	上调
circ_0008253^[37]	OXA抗性	未知	上调
circPRRXl^[38]	ADR抗性	靶向miR-3064-5p和PTPN14基因	上调
circ-LDLRAD3^[39]	DDP抗性、增殖（+）、侵袭（+）	靶向miR-58832-SOX5轴	上调
ciRs-133^[40]	促进脂肪细胞分化	激活miR-133-PRDM16轴	上调