The effect of OSTA index on baPWV in menopausal women and its predictive value for peripheral atherosclerosis

doi:10.11958/20240177

Abstract

Abstract:

Objective To investigate the effect of Osteoporosis Self-Assessment Tool for Asia (OSTA) index on brachial ankle pulse wave velocity (baPWV) and its predictive value for peripheral atherosclerosis in menopausal women. Methods A total of 1 138 menopausal women who underwent physical examination at our hospital from January 2022 to December 2022 were enrolled in the study. General clinical data were collected, the OSTA index was calculated, and baPWV was measured. Patients were divided into the control group (n=539) and the peripheral atherosclerosis group (n=599) according to the baPWV values (peripheral atherosclerosis occurs with baPWV ≥1 400 cm/s). Linear regression and Logistic regression were used to analyze the effect of OSTA index on baPWV in menopausal women. The predictive value of peripheral atherosclerosis was evaluated using the receiver operating characteristic (ROC) curve. Results The OSTA index was lower in the peripheral atherosclerosis group than that in the control group [-0.40 (-2.20, 1.00) vs. 0.40 (-0.60, 1.40), P<0.05]. Univariate linear regression analysis was used to conclude that the OSTA index was an influencing factor of baPWV, and after correcting for risk factors, multivariate linear regression analysis indicated that OSTA index still affected the value of baPWV (P<0.05). The linear regression equation was baPWV= -27.911-39.752×OSTA+6.444×SBP+7.008×DBP+11.506×HCY+27.942×Hs-CRP. Logistic regression analysis suggested that increased OSTA index was a protective factor for peripheral atherosclerosis (OR=0.664, 95%CI: 0.535-0.823, P<0.001). ROC curve analysis suggested that OSTA index was -1.25 as the optimal cutoff point, which predicted peripheral atherosclerosis with an area under the curve of 0.619, a sensitivity of 36.2% and a specificity of 86.3%. Conclusion In menopausal women, OSTA index is an influential factor for baPWV, and increased OSTA index is a protective factor against peripheral atherosclerosis, which can be used to predict baPWV value.

Key words: arteriosclerosis, menopause, peripheral arterial disease, OSTA index, brachial-ankle pulse wave velocity

CLC Number:

R543.5

Figures/Tables 6

References 20

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组别	n		年龄/岁			BMI/（kg/m²）		OSTA指数				SBP/mmHg			DBP/mmHg	吸烟			糖尿病			高血压
对照组	539		54.34±4.14			23.72±2.89		0.40（-0.60，1.40）				116.34±11.29			69.83±8.20	21（3.9）			10（1.9）			21（3.9）
外周动脉硬化组	599		60.06±7.47			24.65±3.04		-0.40（-2.20，1.00）				137.93±17.44			80.72±9.77	269（44.9）			67（11.8）			271（45.2）
t、Z或χ²			16.164^＊＊			5.298^＊＊		7.970^＊＊				25.024^＊＊			20.426^＊＊	251.297^＊＊			41.597^＊＊			254.256^＊＊
组别		FBG/（mmol/L）			HCY/（mmol/L）				TC/（mmol/L）		TG/（mmol/L）		LDL-C/（mmol/L）					HDL-C/（mmol/L）			UA/（μmol/L）
对照组		4.92±0.79			9.56±2.25				4.89±0.52		1.09±0.32		2.72±0.39					1.33±0.17			272.59±49.07
外周动脉硬化组		5.59±1.66			10.26±2.55				4.85±0.56		1.19±0.34		2.76±0.39					1.29±0.18			282.00±46.94
t		8.619^＊＊			4.093^＊＊				0.773		4.621^＊＊		1.286					2.874^＊＊			3.088^＊＊
组别				Cr/（μmol/L）			WBC/（×10⁹/L）			hs-CRP/（mg/L）				LMR			NLR			PLR
对照组				57.93±7.93			5.27±1.02			0.82±1.19				6.68±2.14			1.86±0.73			115.75±38.12
外周动脉硬化组				58.01±8.16			5.70±1.26			1.28±1.65				6.57±2.14			1.97±0.79			112.16±39.46
t				0.151			6.146^＊＊			4.537^＊＊				0.824			2.414^＊			1.496

组别	n		年龄/岁			BMI/（kg/m²）		OSTA指数				SBP/mmHg			DBP/mmHg	吸烟			糖尿病			高血压
对照组	539		54.34±4.14			23.72±2.89		0.40（-0.60，1.40）				116.34±11.29			69.83±8.20	21（3.9）			10（1.9）			21（3.9）
外周动脉硬化组	599		60.06±7.47			24.65±3.04		-0.40（-2.20，1.00）				137.93±17.44			80.72±9.77	269（44.9）			67（11.8）			271（45.2）
t、Z或χ²			16.164^＊＊			5.298^＊＊		7.970^＊＊				25.024^＊＊			20.426^＊＊	251.297^＊＊			41.597^＊＊			254.256^＊＊
组别		FBG/（mmol/L）			HCY/（mmol/L）				TC/（mmol/L）		TG/（mmol/L）		LDL-C/（mmol/L）					HDL-C/（mmol/L）			UA/（μmol/L）
对照组		4.92±0.79			9.56±2.25				4.89±0.52		1.09±0.32		2.72±0.39					1.33±0.17			272.59±49.07
外周动脉硬化组		5.59±1.66			10.26±2.55				4.85±0.56		1.19±0.34		2.76±0.39					1.29±0.18			282.00±46.94
t		8.619^＊＊			4.093^＊＊				0.773		4.621^＊＊		1.286					2.874^＊＊			3.088^＊＊
组别				Cr/（μmol/L）			WBC/（×10⁹/L）			hs-CRP/（mg/L）				LMR			NLR			PLR
对照组				57.93±7.93			5.27±1.02			0.82±1.19				6.68±2.14			1.86±0.73			115.75±38.12
外周动脉硬化组				58.01±8.16			5.70±1.26			1.28±1.65				6.57±2.14			1.97±0.79			112.16±39.46
t				0.151			6.146^＊＊			4.537^＊＊				0.824			2.414^＊			1.496

变量	β	SE	标准化β	t	P
年龄	28.718	1.210	0.576	23.744	<0.001
BMI	16.226	3.290	0.145	4.932	<0.001
OSTA指数	-56.837	4.383	-0.359	12.969	<0.001
SBP	12.959	0.386	0.706	33.588	<0.001
DBP	18.595	0.769	0.583	24.196	<0.001
吸烟	436.370	18.919	0.565	23.065	<0.001
糖尿病	340.217	37.152	0.266	9.157	<0.001
高血压	441.480	18.752	0.573	23.543	<0.001
FBG	76.672	6.629	0.332	11.565	<0.001
HCY	26.448	4.402	0.210	6.008	<0.001
TC	-7.266	23.986	-0.012	0.303	0.762
TG	128.389	33.248	0.131	3.862	<0.001
LDL-C	28.650	32.913	0.033	0.870	0.384
HDL-C	-211.594	76.451	-0.104	2.768	<0.001
UA	0.760	0.203	0.118	3.745	<0.001
Cr	2.350	1.197	0.060	1.963	0.050
WBC	62.958	8.303	0.229	7.583	<0.001
hs-CRP	53.366	7.791	0.237	6.850	<0.001
LMR	-11.275	4.521	-0.075	2.494	0.013
NLR	64.000	12.613	0.152	5.074	<0.001
PLR	-0.224	0.258	-0.027	0.870	0.384

变量	β	SE	标准化β	t	P
年龄	28.718	1.210	0.576	23.744	<0.001
BMI	16.226	3.290	0.145	4.932	<0.001
OSTA指数	-56.837	4.383	-0.359	12.969	<0.001
SBP	12.959	0.386	0.706	33.588	<0.001
DBP	18.595	0.769	0.583	24.196	<0.001
吸烟	436.370	18.919	0.565	23.065	<0.001
糖尿病	340.217	37.152	0.266	9.157	<0.001
高血压	441.480	18.752	0.573	23.543	<0.001
FBG	76.672	6.629	0.332	11.565	<0.001
HCY	26.448	4.402	0.210	6.008	<0.001
TC	-7.266	23.986	-0.012	0.303	0.762
TG	128.389	33.248	0.131	3.862	<0.001
LDL-C	28.650	32.913	0.033	0.870	0.384
HDL-C	-211.594	76.451	-0.104	2.768	<0.001
UA	0.760	0.203	0.118	3.745	<0.001
Cr	2.350	1.197	0.060	1.963	0.050
WBC	62.958	8.303	0.229	7.583	<0.001
hs-CRP	53.366	7.791	0.237	6.850	<0.001
LMR	-11.275	4.521	-0.075	2.494	0.013
NLR	64.000	12.613	0.152	5.074	<0.001
PLR	-0.224	0.258	-0.027	0.870	0.384

变量	β	SE	标准化β	t	P
OSTA指数	-39.752	5.596	-0.260	7.103	<0.001
SBP	6.444	1.311	0.395	4.913	<0.001
DBP	7.008	1.824	0.244	3.843	<0.001
糖尿病	98.287	120.376	0.083	0.816	0.415
高血压	77.680	39.966	0.110	1.944	0.053
FBG	6.450	22.591	0.029	0.285	0.776
HCY	11.506	4.293	0.097	2.680	0.008
TG	6.981	33.649	0.008	0.207	0.836
HDL-C	-22.702	66.422	-0.013	0.342	0.733
UA	0.107	0.233	0.017	0.457	0.648
WBC	-7.696	10.826	-0.028	0.711	0.478
hs-CRP	27.942	8.115	0.129	3.443	0.001
LMR	-1.447	6.252	-0.010	0.231	0.817
NLR	2.401	18.983	0.006	0.126	0.899
常数项	-27.911	199.917	-	0.140	0.889