Mechanism and research progress of mesenchymal stem cell therapy for acute pancreatitis

doi:10.11958/20242422

Abstract

Abstract:

Acute pancreatitis (AP) is an autopeptic disease, which can be accompanied by systemic inflammation and multiple organ failure. Mesenchymal stem cells (MSCs) have been used in the treatment of AP and have shown good application potential. MSCs can act through multiple mechanisms to reduce pancreatic inflammation and enhance tissue repair. These mechanisms include homing to injury sites, anti-inflammatory and immunomodulatory effects, oxidative stress reduction, inhibition of apoptosis and suppression of autophagy. Additionally, MSCs can mitigate multi-organ damage associated with AP, impacting lungs, intestines, heart and other organs. Research on the application of MSCs in treating AP is predominantly at the preclinical animal study stage, with limited clinical investigations reported. This article reviews the mechanisms and research progress of MSCs in the treatment of AP, aiming to provide references for basic research and clinical applications.

Key words: mesenchymal stem cells, acute disease, pancreatitis, severe acute pancreatitis

CLC Number:

R576

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