Clinical efficacy of Jiawei Tai Yuan Yin combined with allylestradiol tablets in the treatment of early threatened abortion complicated with subchorionic hematoma

doi:10.11958/20251153

Abstract

Abstract:

Objective To investigate the clinical efficacy of Jiawei Tai Yuan Yin combined with allylestradiol tablets for the treatment of early threatened abortion complicated by subchorionic hematoma (SCH). Methods A total of 120 patients with early threatened miscarriage combined with SCH were selected and divided into the observation group (Jiawei Tai Yuan Yin + allylestradiol tablets, 60 cases) and the control group (allylestradiol tablets, 60 cases) according to the treatment regimen. Seven days was one course of treatment, and both groups of patients were treated for two courses. Changes of traditional Chinese medicine (TCM) syndrome score before treatment and 14 days after treatment, clinical efficacy, SCH area, the ratio of SCH area to gestational sac area, vaginal bleeding (duration and volume), the miscarriage rate in the early stage of pregnancy, the ratio of auxiliary T cells to inhibitory T cells (Th/Ts) and the level of carbohydrate antigen 125 (CA125) were observed. Results After 14 days of treatment, TCM syndrome scores, SCH area, the ratio of SCH area to gestational sac area, the Th/Ts ratio and the CA125 level were decreased in the two groups, and those of the observation group were lower than those of the control group (P<0.05). After 14 days of treatment, the total effective rate was higher in the observation group than that of the control group (P<0.05). During the treatment period, the duration of vaginal bleeding, the amount of vaginal bleeding and the miscarriage rate in the early stage of pregnancy were lower in the observation group than those in the control group (P<0.05). Conclusion The combination of Jiawei Tai Yuan Yin and allylestradiol tablets can effectively treat early threatened miscarriage with SCH, thereby reducing the miscarriage rate in early pregnancy.

Key words: abortion, threatened, chorion, hematoma, Tai Yuan Yin, allylestrenol, CA-125 antigen, cuscutae semen

CLC Number:

R714.21，R287

Figures/Tables 7

References 17

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组别		年龄/岁	孕周/周		孕次/次		病程/d
对照组		29.17±5.21	10.93±1.04		2.16±0.60		2.16±0.50
观察组		29.85±5.19	10.88±1.09		2.29±0.55		2.29±0.55
t或χ²		0.717	0.094		0.875		0.958
组别	体质量指数/（kg/m²）			受教育年限/年		人工流产史
对照组	24.16±3.20			10.93±1.04		17（28.33）
观察组	24.29±3.25			10.88±1.09		15（25.00）
t或χ²	0.201			0.082		0.170

组别		年龄/岁	孕周/周		孕次/次		病程/d
对照组		29.17±5.21	10.93±1.04		2.16±0.60		2.16±0.50
观察组		29.85±5.19	10.88±1.09		2.29±0.55		2.29±0.55
t或χ²		0.717	0.094		0.875		0.958
组别	体质量指数/（kg/m²）			受教育年限/年		人工流产史
对照组	24.16±3.20			10.93±1.04		17（28.33）
观察组	24.29±3.25			10.88±1.09		15（25.00）
t或χ²	0.201			0.082		0.170

症状	0分	1分	2分	3分
流血量	无	时有时无	量少频发	持续不干净
流血色、质	无	色淡红、质薄	色鲜红、质稠	色深红，质稠
两膝酸软	无	偶尔	时有时无	持续存在
腰部酸痛	无	偶尔	时有时无	持续存在
头晕眼花	无	偶尔	时有时无	持续存在
夜尿频多	无	偶尔	时有时无	持续存在
神疲肢倦	无	偶尔	时有时无	持续存在
心悸失眠	无	偶尔	时有时无	持续存在

症状	0分	1分	2分	3分
流血量	无	时有时无	量少频发	持续不干净
流血色、质	无	色淡红、质薄	色鲜红、质稠	色深红，质稠
两膝酸软	无	偶尔	时有时无	持续存在
腰部酸痛	无	偶尔	时有时无	持续存在
头晕眼花	无	偶尔	时有时无	持续存在
夜尿频多	无	偶尔	时有时无	持续存在
神疲肢倦	无	偶尔	时有时无	持续存在
心悸失眠	无	偶尔	时有时无	持续存在

组别	流血量					流血色、质					两膝酸软
组别	治疗前		治疗后		t	治疗前		治疗后		t	治疗前		治疗后		t
对照组	2.44±0.53		0.61±0.12		26.562^＊＊	2.31±0.69		0.58±0.13		19.085^＊＊	1.37±0.32		0.54±0.13		18.613^＊＊
观察组	2.45±0.52		0.55±0.11		27.690^＊＊	2.33±0.62		0.47±0.12		22.815^＊＊	1.36±0.35		0.43±0.14		19.110^＊＊
t	0.104		2.855^＊＊			0.168		4.816^＊＊			0.163		4.460^＊＊
组别	腰部酸痛					头晕眼花					夜尿频多
组别	治疗前		治疗后		t	治疗前		治疗后		t	治疗前		治疗后		t
对照组	2.01±0.49		0.52±0.12		23.032^＊＊	1.46±0.38		0.65±0.13		14.922^＊＊	1.45±0.37		0.70±0.17		14.273^＊＊
观察组	2.03±0.42		0.43±0.12		28.284^＊＊	1.45±0.33		0.58±0.11		19.373^＊＊	1.43±0.30		0.56±0.10		21.311^＊＊
t	0.240		3.578^＊＊			0.154		2.570^＊			0.279		5.498^＊＊
组别		神疲肢倦							心悸失眠
组别		治疗前		治疗后			t		治疗前			治疗后		t
对照组		1.53±0.30		0.62±0.15			21.016^＊＊		1.55±0.37			0.66±0.15		17.267^＊＊
观察组		1.54±0.31		0.57±0.08			27.690^＊＊		1.56±0.39			0.59±0.13		18.277^＊＊
t		0.179		2.578^＊					0.144			2.732^＊＊