Effect of Magu Xujin capsule on clinical symptoms and bone metabolism after intramedullary nail fixation of proximal humerus fracture

doi:10.11958/20251611

Abstract

Abstract:

Objective To observe the effect of Magu Xujin capsule on clinical symptoms and bone metabolism after intramedullary nail fixation of proximal humerus fracture. Methods Eighty-two patients with proximal humeral fractures treated with intramedullary nailing were randomly divided into two groups, with 41 cases in each group. The conventional group was given routine anti-swelling and pain-relieving symptomatic treatment after surgery, while the experimental group was given Magu Xujin capsules (2 capsules each time, 3 times a day, for 8 consecutive weeks) on the basis of the conventional group. Changes in shoulder joint circumference difference, shoulder joint pain score, Neer shoulder joint function score and callus growth score were compared between the two groups. The serum levels of osteocalcin (BGP), N-terminal osteocalcin (N-MID), bone morphogenetic protein 2 (BMP-2) and blood calcium were detected by enzyme-linked immunosorbent assay. The occurrence of complications and adverse reactions was analyzed in the two groups. Results Changes of shoulder joint circumference difference at 3, 5, 7 and 14 days after surgery were lower than those at 1 day after surgery in both groups, and changes of the shoulder joint circumference difference were smaller in the experimental group at 3, 5, 7 and 14 days after surgery than those in the conventional group (P<0.01). The shoulder joint pain scores in both groups at 3, 5, 7 and 14 days after surgery and at 4 and 8 weeks were lower than those at 1 day after surgery, and the score was lower in the experimental group than that in the conventional group (P<0.01). The serum levels of BGP, N-MID, BMP-2 and blood calcium in both groups at 4 and 8 weeks after surgery were higher than those before surgery (P<0.05), and the levels in the experimental group were higher than those in the conventional group (P<0.05). The Neer scores in both groups at 4 and 8 weeks after surgery were higher than those before surgery (P<0.05). The Neer score and callus growth score at 4 and 8 weeks after surgery were higher in the experimental group than those in the conventional group (P<0.05). In the conventional group, there were two cases of delayed fracture healing and one case of soft tissue infection after surgery. No adverse reactions occurred in either group. Conclusion Magu Xujin capsules can promote the reduction of swelling after intramedullary nail fixation surgery for proximal humeral fractures, alleviate shoulder joint pain, improve bone metabolism and promote the recovery of shoulder joint function.

Key words: fracture fixation, intramedullary, shoulder joint, pain, proximal humeral fracture, Magu Xujin capsule, bone metabolism

CLC Number:

R683.413

Figures/Tables 6

References 23

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组别	n	第1天	第3天	第5天	第7天	第14天	F
常规组	41	35.21±3.36	25.56±2.26^A	18.89±3.12^A	11.77±2.08^A	5.85±1.41^A	91.039^＊＊
试验组	41	34.97±4.02	21.33±2.07^A	13.23±2.12^A	9.45±1.44^A	5.23±1.33^A	99.634^＊＊
t		0.281	8.858^＊＊	9.591^＊＊	5.856^＊＊	2.080^＊

组别	n	第1天	第3天	第5天	第7天	第14天	F
常规组	41	35.21±3.36	25.56±2.26^A	18.89±3.12^A	11.77±2.08^A	5.85±1.41^A	91.039^＊＊
试验组	41	34.97±4.02	21.33±2.07^A	13.23±2.12^A	9.45±1.44^A	5.23±1.33^A	99.634^＊＊
t		0.281	8.858^＊＊	9.591^＊＊	5.856^＊＊	2.080^＊

组别	n	第1天	第3天	第5天	第7天	第14天	第4周	第8周	F
常规组	41	6.25±0.73	5.74±0.64^A	4.86±0.43^A	4.11±0.36^A	3.05±0.29^A	2.23±0.25^A	1.56±0.24^A	167.391^＊＊
试验组	41	6.17±0.74	5.08±0.59^A	4.17±0.39^A	3.36±0.34^A	2.34±0.25^A	1.64±0.22^A	1.02±0.21^A	180.020^＊＊
t		0.436	4.817^＊＊	7.684^＊＊	9.838^＊＊	12.198^＊＊	11.700^＊＊	10.822^＊＊

组别	n	第1天	第3天	第5天	第7天	第14天	第4周	第8周	F
常规组	41	6.25±0.73	5.74±0.64^A	4.86±0.43^A	4.11±0.36^A	3.05±0.29^A	2.23±0.25^A	1.56±0.24^A	167.391^＊＊
试验组	41	6.17±0.74	5.08±0.59^A	4.17±0.39^A	3.36±0.34^A	2.34±0.25^A	1.64±0.22^A	1.02±0.21^A	180.020^＊＊
t		0.436	4.817^＊＊	7.684^＊＊	9.838^＊＊	12.198^＊＊	11.700^＊＊	10.822^＊＊

组别	n	第1天	第3天	第5天	第7天	第14天	第4周	第8周	F
常规组	41	7.36±0.85	6.14±0.77^A	5.21±0.64^A	4.87±0.46^A	3.74±0.43^A	2.91±0.37^A	2.13±0.25^A	77.294^＊＊
试验组	41	7.41±0.79	5.60±0.69^A	4.77±0.53^A	4.11±0.42^A	3.12±0.38^A	2.24±0.31^A	1.48±0.23^A	90.011^＊＊
t		0.274	3.382^＊＊	3.475^＊＊	7.828^＊＊	6.972^＊＊	8.895^＊＊	12.019^＊＊