MDT treatment strategy for organophosphorus and anticoagulant rodenticide poisoning in an elderly patient with depression

doi:10.11958/20252004

Tianjin Medical Journal ›› 2025, Vol. 53 ›› Issue (9): 1000-1004.doi: 10.11958/20252004

• Multidisciplinary Diagnosis and Treatment • Previous Articles Next Articles

MDT treatment strategy for organophosphorus and anticoagulant rodenticide poisoning in an elderly patient with depression

FU Shasha¹(), JIA Yue¹, SHAO Hongxia², GUO Yu¹, MA Longyan³, HAN Tong¹, SUN Hao¹, YU Hongzhi¹^,^△()

1 Department of Critical Care Medicine, Tianjin University Haihe Hospital, Tianjin 300350, China
2 Department of Infectious Diseases, Tianjin University Haihe Hospital, Tianjin 300350, China
3 Department of Emergency, Tianjin University Haihe Hospital, Tianjin 300350, China

Received:2025-05-16 Revised:2025-06-12 Published:2025-09-15 Online:2025-09-16
Contact: ^△E-mail: 13512205663@163.com

FU Shasha, JIA Yue, SHAO Hongxia, GUO Yu, MA Longyan, HAN Tong, SUN Hao, YU Hongzhi. MDT treatment strategy for organophosphorus and anticoagulant rodenticide poisoning in an elderly patient with depression[J]. Tianjin Medical Journal, 2025, 53(9): 1000-1004.

Abstract

Abstract:

Organophosphorus pesticide (OP) is one of the most widely used pesticides in the world with the largest dosage. Acute organophosphorus pesticide poisoning (AOPP) is a common clinical disease, and AOPP accounts for 20%-50% of poisoning cases in China every year, with case fatality rate of 3%-40%. Bromophos (BDF) is a long-acting anticoagulant rodenticide, which inhibits vitamin K epoxide reductase and interferes with the synthesis of coagulation factors Ⅱ, Ⅶ, Ⅸ and Ⅹ, leading to coagulation dysfunction. This article discusses the multidisciplinary diagnosis and treatment (MDT) process of a patient with combined poisoning of dichlorvos and bromadiolone. The article explores blood purification, management of coagulation abnormalities, secondary infection, atropinization and altered consciousnes in patients with organophosphorus poisoning and anticoagulant rodenticide compound poisoning, with the aim of providing clinicians with references for early diagnosis and treatment.

Key words: organophosphate poisoning, blood coagulation disorders, consciousness disorders, coinfection, rodenticide poisoning, atropinization, multidisciplinary diagnosis and treatment

CLC Number:

R595.5

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References 14

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MDT treatment strategy for organophosphorus and anticoagulant rodenticide poisoning in an elderly patient with depression

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