Effect of photodynamic therapy combined with supramolecular salicylic acid on patients with moderate to severe acne

doi:10.11958/20252842

Abstract

Abstract:

Objective To investigate the effect of photodynamic therapy (PDT) combined with supramolecular salicylic acid on skin physiological parameters and serum levels of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) in patients with moderate to severe acne. Methods Two hundred patients with moderate to severe acne were selected and randomly divided into the observation group (treated with PDT combined with supramolecular salicylic acid, n=100) and the control group (treated with PDT alone, n=100) according to the random number table method. The clinical efficacy, lesion scores, skin physiological indicators, IFN-γ, TNF-α levels and adverse reactions were compared between the two groups. Results The total effective rate was higher in the observation group than that of the control group (95.0% vs. 86.0%，P<0.05). After treatment, the lesion scores of comedones, papules, pustules, cysts, total lesion scores, skin oil content and serum TNF-α levels were lower in the observation group than those of the control group, while the skin water content, pH value and serum IFN-γ levels were higher in the observation group than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (11.0% vs. 12.0%，P>0.05). Conclusion PDT combined with supramolecular salicylic acid is effective in the treatment of moderate to severe acne. It can effectively improve the condition of skin lesions and skin physiological indicators, regulate serum levels of inflammatory factors, and has good safety.

Key words: acne vulgaris, aminolevulinic acid, tumor necrosis factor-alpha, interferon-gamma, photodynamic therapy, supramolecular salicylic acid

CLC Number:

R758.733

Figures/Tables 7

References 18

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组别		性别				年龄/岁
组别		男		女		年龄/岁
对照组		56（56.00）		44（44.00）		25.66±4.23
观察组		55（55.00）		45（45.00）		25.12±4.17
χ²或t		0.020				0.909
组别	体质量指数/ （kg/cm²）		痤疮分级
组别	体质量指数/ （kg/cm²）		Ⅱ		Ⅲ		Ⅳ
对照组	24.39±5.25		36（36.00）		36（36.00）		28（28.00）
观察组	24.68±5.02		35（35.00）		40（40.00）		25（25.00）
χ²或t	0.399		0.394

组别		性别				年龄/岁
组别		男		女		年龄/岁
对照组		56（56.00）		44（44.00）		25.66±4.23
观察组		55（55.00）		45（45.00）		25.12±4.17
χ²或t		0.020				0.909
组别	体质量指数/ （kg/cm²）		痤疮分级
组别	体质量指数/ （kg/cm²）		Ⅱ		Ⅲ		Ⅳ
对照组	24.39±5.25		36（36.00）		36（36.00）		28（28.00）
观察组	24.68±5.02		35（35.00）		40（40.00）		25（25.00）
χ²或t	0.399		0.394

组别	痊愈	有效	无效	总有效
对照组	60（60.0）	26（26.0）	14（14.0）	86（86.0）
观察组	70（70.0）	25（25.0）	5（5.0）	95（95.0）
χ²				4.711^＊

组别	痊愈	有效	无效	总有效
对照组	60（60.0）	26（26.0）	14（14.0）	86（86.0）
观察组	70（70.0）	25（25.0）	5（5.0）	95（95.0）
χ²				4.711^＊

组别	粉刺					丘疹
组别	治疗前		治疗后	t		治疗前	治疗后		t
对照组	2.96±0.58		0.50±0.14	41.229^＊＊		2.45±0.62	0.54±0.15		29.943^＊＊
观察组	2.95±0.52		0.43±0.11	47.412^＊＊		2.44±0.65	0.43±0.10		30.564^＊＊
t	0.121		3.932^＊＊			0.111	6.102^＊＊
组别		脓疱
组别		治疗前			治疗后			t
对照组		1.55±0.47			0.88±0.22			12.911^＊＊
观察组		1.58±0.45			0.66±0.14			19.522^＊＊
t		0.461			8.437^＊＊
组别	囊肿					皮损总积分
组别	治疗前		治疗后	t		治疗前	治疗后		t
对照组	1.87±0.38		0.65±0.14	30.126^＊＊		9.43±1.14	2.43±0.54		55.493^＊＊
观察组	1.85±0.32		0.44±0.11	41.669^＊＊		9.44±1.12	2.03±0.52		60.008^＊＊
t	0.403		6.178^＊＊			0.063	5.336^＊＊