Abstract: Abstract: Objective To explore related factors affecting bone mineral density (BMD) and osteoporosis (OP) in pa⁃ tients with type 2 diabetes mellitus (T2DM). Methods Dual-energy X-ray absorptiometry was used to measure BMD of the femoral neck and the lumbar vertebrae in 220 patients with T2DM. All the patients were divided into three groups: normal bone mass group, decreased bone mass group and OP group according to the value of BMD. The clinical data and biochemi⁃ cal indicators were compared and analyzed between these groups, and the influencing factors of T2DM and OP were ex⁃ plored. Results Compared with normal bone mass group and decreased bone mass group, there were more older patients, longer course of T2DM, lower BMI and high density lipoprotein cholesterol (HDL- C), and higher glycated hemoglobin (HbA1c) level in OP group. There were significantly higher age, longer course of T2DM, higher level of HbA1c, and lower levels of BMI, HDL-C in decreased bone mass group than those of normal bone mass group (P<0.05). There were no signifi⁃ cant differences in waist-to-hip ratio, systolic blood pressure (SBP), diastolic blood pressure (DBP), postmenopausal women (PMW) ratio, fasting plasma glucose (FPG), 2-h postprandial blood glucose (2hPG), blood phosphorus, calcium, total choles⁃ terol (TC), three acyl glycerin (TG) and low-density lipoprotein cholesterol (LDL-C) between three groups. The risk factors for T2DM combined with OP were older, female, long duration of T2DM, higher levels of FPG, 2hPG and HbA1c. Conclu⁃ sion Older and female T2DM patients were high-risk group of OP. The treatment plan should be timely adjusted by regular⁃ ly monitoring indexes of blood glucose and HbA1c.

Key words: diabetes mellitus, type 2, osteoporosis, bone density, risk factors, female, age factors