Abstract: Abstract： Objective To explore the correlation of maternal serum and newborn cord blood total IgE and childhood atopic dermatitis (AD), as well as its clinical significance of allergen testing. Methods Selected 35 cases which were diagnosed as AD(AD group), and randomly selected 35 cases of the baby who were not diagnosed as AD (control group) from a birth cohort established in 2009—2011.Detected maternal serum and newborn cord blood total IgE level by the ELISA method. Used quantitate immunoblotting method to detect serum specific IgE antibody level. Results The serum total IgE level of the mothers and cord blood in the AD group are significantly higher than the control group (χ2=16.568 and 14.933，P < 0.01). Compared to the control group, there was statistical significance of dust mites, house dust, ragweed pollen, song kind of pollen, poplar, surname and elm pollen, mould, shrimp, marine fish of mother serum allergen in AD group（P < 0.05）; there was statistical significance of song kind of pollen, mould of newborn cord blood in AD group（P < 0.05）. Conclusion Advanced mother serum total IgE may play a predictive effect on infants suffering` from AD.There is no obvious consistency in allergic state between mothers and infants.

Key words: dermatitis atopic, fetal blood, immunoglobulin E, atopic dermatitis, cord blood, maternal serum, total IgE,
specific IgE, allergen test