Abstract: Abstract: Objective to investigate the dynamic changes of the levels of plasma D-dimer, C-reactive protein (CRP) and fasting plasma glucose (FBG) in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with type 2 diabetes mellitus. Methods AECOPD group(n=65) as A group , AECOPD combined with type 2 diabetes mellitus group(n=65) as B group, The levels of D-dimer, CRP and FBG were observed and compared in the first day, third day, seventh day and the 14th day after hospital admission in two groups, and the correlation analysis between D-dimer, CRP and FBG. Logistic regression analysis of the factors that increased plasma levels of D-dimer. Results The levels of D-dimer, CRP and FBG of B group were higher than A group in the first day, third day and the seventh day after hospital admission（P<0.01）, D-dimer and CRP in A group declined obviously in the seventh day after hospital admission, but in B group declined obviously until the 14th day. In A group there was no significant difference on FBG, In B group FBG significantly decreased. there was a positive correlation between CRP,D-dimer and FBG（P<0.05）.Logistic regression analysis showed that CRP, FBG, p（O2）and age were the influence factors for the increased levels of D-dimer . Conclusion in elderly patients with AECOPD combined with type 2 diabetes mellitus, we should pay attention to anti-inflammatory and controlling blood sugar, at the same time dynamic monitoring for the levels of D-dimer, that help to improve the clinical and prognosis for patients with COPD, and reduce mortality.

Key words: pulmonary disease, chronic obstructive,  diabetes mellitus, type 2,  C-reactive protein,  aged, D-dimer