Tianjin Medical Journal ›› 2015, Vol. 43 ›› Issue (7): 830-833.doi: 10.11958/j.issn.0253-9896.2015.07.035

Previous Articles    

Research advances in IL-33 and its receptor ST2L in allergic rhinitis

DU Yunyan, LUO Ying, WAN Jun, YANG Chunping, YANG Ying, HE Rongzhou   

  1. The Otolaryngology Head and Neck-Surgery of the Second Affiliated Hospital of Nanchang University, Nanchang

  • Received:2014-12-23 Revised:2015-01-06 Published:2015-07-15 Online:2015-07-15
  • Contact: LUO Ying△ E-mail:695728274@qq.com

Abstract: Allergic rhinitis (AR) is a specific individual after contact with allergens of the performance of a noninfectious inflammatory response in the nasal mucosa.Th1/Th2 immune imbalance may play an important role in the pathogenesis of AR.Interleukin 33 (IL-33), the novel cytokine of IL-1 family,is an important regulatory factor in allergic diseases, autoimmune diseases and various inflammatory diseases.IL-33 as an alarm, mainly by the secretion and release of tissues and cells damaged, especially impaired epithelial cells and endothelial cells.IL-33 binding to its receptor ST2L can activate a variety of immune cells to produce Th2 cytokines, precipitating and maintaining Th2 polarization, increased AR immune inflammation, which is the new targeted of AR in research and treatment. In this article,we will do a brief overview for the biological functions of IL-33 and its receptor ST2L and the research progress in the AR.

Key words: interleukin-33, allergic rhinitis, ST2L, Th2-type response, asthma, review