›› 2014, Vol. 42 ›› Issue (12): 1243-1245.doi: 10.3969/j.issn.0253-9896.2014.12.026

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Review the Function and Structure of Interleukin-35 and Its Function in Mediating Treg Cell Immuno-Suppression

YAN Yongjia ,HE Xianghui   

  1. Department of General Surgery, the General Hospital of Tianjin Medical University, Tianjin 300052, China
  • Received:2014-02-21 Revised:2014-07-11 Published:2014-12-15 Online:2014-12-15
  • Contact: HE Xianghui E-mail:humphreyhe@163.com

Abstract:

[Abstract] Interleukin (IL)-35 is a new member of IL-12 family who is secreted by T regulatory cells to strongly sup? press immuno reaction directly or indirectly. There is a growing interest in the using IL-35 as a potential therapy for chronic in? flammatory , cancer and autoimmune diseases. Here we reviewed IL-35 and its function as a mediator of suppression.

Key words: T-lymphocytes, regulatory, autoimmune diseases, immune tolerance, IL-35, iTR35 cells