Abstract: Immune tolerance is the ultimate goal of organ transplantation. Although there are many studies in immune tolerance after transplantation, most of them are in the experimental stage, with seldom programs applied in patients.Compared to regulatory T cells, donor specific regulatory T cells are less investigated in immune tolerance, because of lower percentages and difficult preparing methods. This paper will summarize the hotspots of researches related to donor-specific regulatory T cells in recent years from the generality of regulatory T cells, suppressive function of donor specific regulatory T cells, culture technique in vitro and thymus transplantation, in order to provide new ideas to clinical research.

Key words: regulatory T cell, organ transplantation, immune tolerance, donor