Abstract: Abstract： Erythropoietin (EPO) is an active glycoprotein synthesized by kidney. The physiological function of regulat⁃ ing the synthesis of erythrocytes by EPO makes it as a clinical drug for treatment of anemia resulted from chronic kidney fail⁃ ure. However, its short biological half-life makes frequent administration, which limits its wide clinical utility since the tough burden and pain on patients. Therefore, the development of EPO derivatives with good efficacy, less adverse reaction and long duration has been a hot spot in the field during several decades. There are currently many different variants of EPO derivatives including erythropoiesis stimulating agents (ESAs) on the market. This article aims to summarize the recent re⁃ search progress in the development of erythropoietin derivatives, specially focusing on EPO mimetic peptides (EMP).

Key words: erythropoietin, erythropoietin, recombinant, receptors, erythropoietin, anemia;erythropoietin mimetic peptide