Abstract: Abstract Objectives: To discuss the relation between E-selectin gene A561C polymorphism and T2DM. Methods：Using PCR-RFLP way, the A561C polymorphism was screened in 112 DM and 140 controls, and analyze clinical data. Results： 12 with the heterozygote mutation (AC) were found in 112 DM patients, and the C allele frequency is 5.36%. 4 were found in 140 controls, and C is 1.43%. It has statistics differences (P <0.05). No homozygote mutation (CC) in the two groups. DM group is higher than the control group in SBP, BMI, TC, TG, LDL, FPG, P2PG and FINS. It has statistics difference（P <0.05）. From the genotype, AC is higher than AA in FPG, P2PG and FINS. It has statistics difference（P <0.05）. Conclusions: It shows that the mutation may be the susceptibility gene in the Han nationality population in Tianjin ,and plays an important role in the occurrence and development of DM.

Key words: type 2 diabetes mellitus, E-selectin, gene polymorphism, gene frequency