Abstract: Objective To study the vascular endothelial function and the quantity of endothelial progenitor cells（EPCs） from peripheril blood in the newly diagnosed type 2 diabetes(T2DM) and the related factors . Methods Endothelial-dependent vasodilation(EDV), The function of EPCs，High sensitive C reactive protein(hsCRP )， insulin active index(IAI)， blood glucose and blood-fat were measured in controls and newly diagnosed T2DM. Results The quantity of EPCs were significantly reduced in T2DM,EDV and IAI were lower in T2DM than that in Control group. Conclusions These findings suggest that the quantity of EPCs and endothelial function were decressed and these factors were closed related with IAI，hsCRP and the level of blood glucose.

Key words: Type 2 diabetes, endothelial function, endothelial progenitor cells, insulin resistence