Abstract: Abstract: Objective To explore the effects and influencing factors of short-term comprehensive intervention on blood glucose control in obese or overweight patients with type 2 diabetes mellitus. Method: Baseline questionnaire survey (including gender, age, diabetes-related information), physical measurement (height, weight, waist circumference, etc.) and biochemical tests (including fasting blood glucose (FPG), postprandial 2H blood glucose (2h PBG) and glycosylated hemoglobin (HbA1c)) were conducted in 47 hospitals in Tianjin in 2018. Biochemical indicators after 3 months of intervention were included. χ^2 test, univariate and multivariate unconditional logistic regression were analyzed by using SAS statistical package. Results Among 987 diabetic patients with overweight or obesity, 738 (74.8%) were obese and 872 (88.3%) were central obese. There were significant differences in blood sugar indexes before and after comprehensive intervention (P < 0.001); the effective rate of 3-month intervention was 65.75% (649/987). Univariate unconditional logistic regression analysis showed that age, course of disease and regularity of three meals were statistically significant. (P < 0.001); Multivariate logistic regression analysis showed that normal diet was an effective protective factor for 3-month comprehensive intervention (OR = 1.992, 95% CI: 1.466-2.706), course of disease (> 10 years) (OR (95% CI): 10-15 years: 0.555 (0.37-0.831); course (> 15 years: 0.546 (0.357-0.834)) and age (> 60 years) (OR = 0.604, 95% CI: 0.404-0.904) are risk factors for effective 3-month comprehensive intervention. Conclusion Comprehensive intervention for obese and overweight patients with T2DM can effectively improve the standard rate of glycosylated hemoglobin and reduce the blood sugar levels of patients. At the same time, it is suggested to establish and improve the comprehensive intervention system to improve the blood sugar standard rate of this population.

Key words: comprehensive intervention, Type 2 diabetes, overweight or obesity, glycosylated hemoglobin, influencing factors