Abstract: Effect of Xuebijing Injection on the Systemic Inflammatory Response Syndrome of the Patients of Severe Acute Organophosphorus Poisoning （Li Xiangmin,Department of Emergency,Xiangya Hospital ,Central South University, Changsha 410008,Hunan,China） Abstract Objective The aim of this study was to explore the protective effect of Xuebijing Injection on the systemic inflammatory response syndrome (SIRS) of the patients of severe acute organophosphorus poisoning (AOPP) and its mechanisms. Methods 45 patients of severe acute organophosphorus poisoning were studied. They were randomly divided into two groups: the group treated with Xuebijing Injection (23 patients), and the routine treatment group (19 patients). In the former group, besides the routine treatment, the patients were treated with Xuebi Jing Injection additionally. The temperature (T), heart rate (HR), respiratory rate (RR), white blood cells (WBC), C-reactive protein (CRP), tumor necrosis factor (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8) of the patients before the treatment and on the 1st, 3rd and 5th days with the treatment were compared. Results After 3-day treatment, compared with the routine treatment group, the temperature, HR, RR, WBC and CRP of the patients in the group treated with Xuebijing Injection were significantly improved ( P< 0.01 or P< 0.05). The TNF-α、IL-6、IL-8 of them were significantly reduced (P<0.01). After 5-day treatment, the effects were more significant. Conclusions Xuebijing Injection can effectively inhibit the systemic inflammatory response syndrome of the patients of severe acute organophosphorus poisoning, significantly improve the symptoms of SIRS, and it might play a very important part in helping treat the AOPP patients.

Key words: Xuebijing, Acute organophosphorus poisoning, systemic inflammatory response syndrome, Tumor necrosis factor