Abstract: Objective To investigate the feasibility and of Video-assisted thoracoscopic thymectomy. Methods Twenty-six patients with thymic diseases received video-assisted throacoscopic surgery（VATS）between January 2007 and December 2009.There were 18 male and 8 female，aged 17 to 62，mean 43.1years. 21 total thymectomy and 5 extended thymectomy for myasthenia gravis（MG）were performed. Results Complete thymectomy was achieved in every case. Postoperative temporary mechanical ventilation （3d）was required in 2 patients with MG. There was no other severe complications and no mortality. Conclusions Video-assisted thoracoscopic thymectomy is safe and effective with the advantage of less invasion，quick recovery and less complications.