Abstract: [Abstract] Objective To explore the clinicopathological characteristics and prognostic factors of pediatric Rhabdomyosarcoma by the retrospective study of clinical and survival data of 93 patients,who were diagnosed RMS.Method The clinical datain cluding sex,age,tumor size,primary site, histological subtypes, COG-staging,COG-grouping,risk classification and surgery were analyzed. We used multi-variety analysis with COX regression model to identify the independent prognosis factors,Influence of the above factors on the survival rate was analyzed by Kaplan-Meier curve and Log-rank test. Results Survival rates of 1-,3-and 5-year in pediatric were 90.3%,62.0%,43.1%,respectively,and the median overall survival time was 19.43 months. Multivariable analysis showed that the histological subtypes, primary site , COG-grouping and surgical resection are independent prognosis factors.The survival analysis showed that there were significant ststistical differences in the prognostic differences of the histological subtypes（P＜0.001）, primary site （P＜0.001）, COG-grouping（P＜0.001） and surgical resection（P＜0.001）.Conclusion The independent prognosis factors of pediatric Rhabdomyosarcoma including histological subtypes, primary site,COG-grouping and surgical resection.It can be used to predict the prognosis and provide the basis data for clinical treatment.