Abstract: Abstract：Objective: To determine the protective effect on intestine of propofol after hemorrhagic shock and resuscitation by measuring the changes of intestinal SOD and MDA and plasma DAO levels. Method: Thirty Wistar rats were randomized into 3 groups: sham operation group, resuscitation group and propofol group. There were 10 rats in each group. To establish animal models of hemorrhagic shock and resuscitation. Following resuscitation, the resuscitation group was infused normal saline at 1ml/kg/h with infusion pump for 2 hours, the propofol group was infused propofol at 1ml/kg/h for 2 hours. Then sampling in each group. Results: The MDA and DAO levels in the resuscitation group and the propofol group were higher than those in the sham operation group (P<0.5)，Propofol group was lower than resuscitation group(P<0.5) ; but SOD levels were lower than those in the sham operation group (P<0.5), Propofol group was higher than resuscitation group(P<0.5). Conclusion: The intestinal tissue was significantly damaged after hemorrhagic shock and resuscitation, propofol can reduce this damage by against the oxygen free radicals.

Key words: propofol, shock, intestine injury, protect