Abstract: 【Abstract】 Objective: Evaluate the effect of P-15 peptide attachedβ- tricalcium phosphate (β-TCP )surface on cellular compatibility in vitro. Methods: myoblast C2C12 treated by BMP2 was cultured on the surface ofβ-TCP/P-15 and β-TCP, samples were obtained 2、4、6 days after culture.Cell proliferation was detected by CCK8 method;Cell alkaline phosphatase activities were assayed by ALP kit;Total cell protein was examined by BCA method. Results: The cell proliferation、ALP activity and total amount of protein of C2C12 adhered to β-TCP attched by P-15 peptide were obviously higher than that of C2C12 adhered toβ-TCP Conclusion: β-TCP surface attached P-15 improve its biocompatibility.

Key words: β-TCP, P-15, Cellular compatibility, Myoblasts , BMP2