Abstract: 【Abstract】　Objective: To study the characteristics of insulin resistance and pancreatic β- cell function in pregnant women with different abnormal glucose tolerance conditions，reveal the difference of insulin resistance and pancreatic β- cell secretion in abnormal glucose metabolism course Methods: Collected 504 patients with normal body mass index 、regular antenatal care and 50Ggct(+)in our hospital , without diabetes history and other pregnancy complications,who carried out oral glucose torelance test (OGTT) and insulin release test. Classified into normal glucose tolerance (NGT) , isolated impaired fasting glucose ( GIGT0) , isolated impaired glucose tolerance after drinking glucose water 1 hour(GIGT1)、2 hour(GIGT2)、3 hour(GIGT3)and Gestational diabetes mellitus (GDM) groups based on OGTT result according to ADA. HOMA-IR 、HOMA-β、and △PI/△PG of different groups were statistically analyzed by SPSS10.0. Results : 1、The trend of different time points in abnormal glucose metabolism course were not same. 2、Compared to NGT group , HOMA-IR was increased by 36.4%、22.5%、19.7%、6.4% and 39.9% respectively in GIGT0、GIGT1、GIGT2、GIGT3andGDM。3、The level of HOMA-β was decreased by 11.7%、6.5%、7%、1.4% and 12.3% respectively in GIGT0、1、2、3andGDM；△PI/△PG ratio was decreased in GIGT0、1、2、3 and GDM，but the diversity had statistical significance in NGT and GDM group only（P<0.05）。Conclusion: Patients with abnormal glucose metabolism not only have stronger IR compared with normal pregnancies ,but also have significant decline in pancreatic β- cell function. GIGT is actually a heterogeneous metabolic disorder，GIGT3 was resembles that of NGT, andGIGT0、GIGT1 of GIGT were seem as GDM ，both conditions are characterized by increased of glycemia, insulin resistance, and decreased β- cell function.So we should strengthen the administration to abnormal glucose metabolism patients,intervention as early as possible ，in order to decreased the complications .

Key words: Gestational diabetes mellitus, Insulin resistance, β- cell function