Abstract: Abstract Objective：To fabricate porous PGA/β- Tricalcium Phosphate of tissue engineering scaffolds and test its properties. Methods: Used PGA andβ- Tricalcium Phosphate as materials, 1,1,1,3,3,3-Hexafluoro-2-propanol as solvent, sodium chloride as porogen(particle size :425–500μm), the PGA/β-TCP（in 1：1and 1：3 weight ratios ） scaffolds for tissue engineering are fabricated by solvent-casting particulate leaching and methods. The structure of the scffolds were observed using scanning electron microscopy (SEM). Their properties of physical and mechanics are tested in this paper. Result: The compressive strength of the 0.13gPGA/0.39gβ-TCP（B）group were obviously higher than that the compressive strength of the 0.13gPGA/0.13gβ-TCP（A）group P＜0.001. The compressive strength of the A and B group after surgery were: 731.283±55.2140KPa, 173.833±36.1397KPa. Both A and B groups have a high porosity.(＞85%). The opening porosities of PGA/β-TCP (1:1) scaffolds and PGA/β-TCP (1:3) scaffolds were 93.1±0.7% and 89.3±0.6%, respectively, which is a statistically significant difference . The SEM pictures showed that both scaffolds had irregular micro-pores .The average pore size of two groups were 300-400μm,the β-TCP particles were uniformly dispersed within the PGA matrix.The different between the two groups was that moreβ-TCP granules were present on the pore wall surface of group B compared to group A. Conclusion: The weight ratios (1:3) scaffolds materials can basically meet the requirements of materials for bone tissue engineering.

Key words: bone tissue engineering, scaffolds, polyglycolic acid, composites, β- Tricalcium Phosphate