Abstract: Objective To investigate the anti-inflammatory effect of the plantain seed polysaccharides (PSP). Methods Various inflammatory models, including the swelling of ear induced by xylene in mice, the permeability of blood capillary by acetic acid in mice, viewing earlier period Anti-inflammatory Effect of PSP. Then, air sac models of synovitis in mice were set up, the amount of white blood cell (WBC), the volume and the contene of tumor necrosis factor (TNF-a) were measured in inflammatory exudan, the activity of superoxide dismutase (SOD), the contene of malondialdehyde (MDA) were measured in inflammatory exudan and blood serum to observe intermediate stage anti-inflammatory effect of PSP and the influence on above-mentioned index. Meanwhile, through the cotton-pellet granuloma of the mice, viewing advanced stage anti-inflammatory effect of PSP. Results The PSP had significant inhibitory action on auris swell induced by xylene in mice, penetration of capillary vessel in mice and the proliferation of granuloma caused by implantation cotton-pellet in mice. The amount of WBC 、the volume 、the contene of tumor necrosis factor(TNF-a) in inflammatory exudan, and the content of MDA in inflammatory exudan and blood serum were obviously lower than those in the control groups. The activity of SOD was obviously higher. Conclusion The PSP has significant anti-inflammation, which is relevant to the inhibition of the effusion on the inflammatory factor, the elimination of the free radicle and inhibition of the lipid peroxidation.

Key words: Plantain Seed Polysaccharides, Superoxide Dismutase, Malondialdehyde, Tumor Necrosis Factor-alpha Anti-Inflammatory Effect