Abstract: Objective : to evaluate the efficacy and safty of thrombolysis by intravenous rt-PA in acute cerebral infarction. Methods: 22 cases of acute ischemic stroke patients with intravenous thrombolysis; Onset time from thrombolysis within 3h， program for the 0.9 mg/kg， maximum dose 90mg. The total dose of 10％ mixing in syringes，In 1 min injection. The remaining 90% liquid is added to an infusion pump, the static point, sustained over 1 h. A control group of 21 patients treated with conventional therapy. Outcome measures：Two groups before and after treatment with NHISS score and Barthel index ( BI)。A modified Rankin scale 90d integrated living ability。Safety index:Death， bleeding， and other Adverse events .Results: After thrombolytic therapy in patients with 24h， 14d， 90d NHISS score decreased significantly compared with the control group， the difference was statistically significant ( P < 0.05). After treatment, 24h, 14d, 90d thrombolysis group BI scores were higher than that of the control group. There were statistically significant ( P < 0.05 ), especially in the thrombolysis after 24hBI score than the control group improved more obviously ( P < 0.01 ). 90 d follow-up, the BI score and mRS score significantly benefit from thrombolysis group than in the control group, the difference was statistically significant ( P < 0.05 ) Two groups of overall adverse events and serious adverse events have no obvious difference, without statistical significance ( P > 0.05 ). Conclusion: Early rt-PA intravenous thrombolysis in treating acute cerebral infarction is effective and relatively safe method.

Key words: acute cerebral infarction, intravenous thrombolysis, rt-PA, Observation of curative effect