Abstract: Abstract Objective:to analyze the cerebral evoked potentials and blink reflex characteristics of coma patients, and combined with Glasgow (GCS) score to approach its prognostic value in patients with coma. Methods: 40 score of GCS 3-12 comatose in ICU ward were examined by brainstem auditory evoked potential (BAEP)、somatosensory evoked potential(SEP) and blink reflex(BR) in 24 hours after coma，at the same time,the GCS、clinical assessment of brainstem reflex was performed,motion detection and observe the patients’ prognosis.BAEP, SEP use Cant grading standards, BR grouped according to test results, the prognosis is divided into death, persistent coma state, improved. Results: of the 40cases, 23 patients died,13 cases in persistent coma state, 4 cases improved.BAEP examination unilateral or bilateral Ⅲ ~ Ⅴwaves are missing(Cant grade Ⅲ) in 15 cases, 14 died,the mortality rate was 93%. Unilateral or bilateral SEP N20disappeared (Cant grade Ⅲ) in 22 cases, 17died, the mortality rate was 77%. BR of all patients in the acute coma state were different degrees of abnormality, of which 30 cases were no response, and prognosis was not statistically significant(χ2=1.989,P=0.370).BAEP, SEPCant grade were grade Ⅲ in 10 cases, 9 cases GCS score of 3 points, 1 case GCS score of 4 points, all died within one month, the mortality rate was100%. Conclusions:BAEP, SEP can effectively predictthe prognosis of comatose patients at certain extent,their combination can significantly improve the affect of prognosis assessment, BR in the acute state of coma were different degrees of abnormality,can not accurately predict the prognosis.

Key words: Brainstem auditory evoked potential, Somatosensory evoked potential, Blink reflex, GCS score, Coma, Prognosis