Abstract: 【Abstract】Objective To assess the clinical effects of mild hypothermia and hyperbaric oxygen injection following by severe traumatic brain injury. Methods According all 157 patients with acute severe traumatic brain injury were divided into mild hypothermia group (54 patients), hyperbaric oxygen with mild hypothermia group (48 patients) and routine treatment group (55 patients) randomly. The therapeutic effect was evaluated at the 3rd month after injury by Glascow Outcome Scale (GOSs). One hundred and one patients (vegetable alive and dead patients were not included) were evaluated at the 3rd month after injury by Barthel Index. Result In comparison with other two groups, there was a higher mortality rate in routine treatment group (P<0.05). There were significant difference for recovery rate in three groups (P<0.05). Conclusions Mild hypothermia was an effective way to severe traumatic brain injury, which could reduce the mortality rate and improve the prognosis without severe complications. The hyperbaric oxygen injection had some effect for recovery.

Key words: Mild hypothermia, Traumatic brain injury, Hyperbaric oxygen