Abstract: 【ABSTRACT】Objective: To investigate the effects of oxidative stress on multiple organ edema in the rats which suffered from hind limb ischemia-reperfusion(LIR）and the precaution of Salvia miltiorrhiza. Methods: 24 Wistar rats were randomly divided into 3 groups: control group(C), ischemia-reperfusion group(I/R) and Salvia miltiorrhiza group(SM). Referring to routine method in our department, the model rats which underwent 4 hours ischemia and 4 hours reperfusion of hind limbs were made. 30 minutes before reperfusion, SM was given to the rats in SM group by tail vein injection at the dose of 5 ml／kg．Accurately weigh one gram of heart, liver, kidney, lung, brain, intestine and skeletal muscle from every animals，weigh these specimens after baking(60℃,55 hours), Calculated the ratio of wet and dry (W/D) .Measured the activity of SOD and the levels of XOD and MDA in plasma. The morphologic changes of those tissue samples were observed with microscope. Results: It was found that after suffering from ischemia-reperfusion, the W/D of every specimens increased in different degree（P<0.01 or P<0.05）. In plasma, the values of SOD decreased but XOD and MDA increased obviously（P<0.01 or P<0.05）. After LIR, disordered arrangement ,broaden interstitial and infiltration of inflammatory cells of sample can be seen in different degree under microscope. However, Compared with I/R group, all organs’ W/D in SM group are lower, The values of SOD in plasma increased but XOD and MDA in plasma falled down（P<0.01 or P<0.05.Pathological changes in every tissue were reduced. Conclusion: Limb ischemia-reperfusion can lead to multiple organ edema, oxidative stress is one of the important mechanisms. Salvia miltiorrhiza might be play the role of anti-edema by anti-oxidation.