Abstract: Objective To investigate the influence of anesthesia methods and anesthetics on anti-inflammatory cytokines in the intracranial neoplasms. Methods One hundred six ASA Ⅰ or Ⅱ patients undergoing for selective intracranial neoplasms surgery were divided randomly into two groups with 53 cases each. The patients in group P were given intravenous anesthesia with target controlled infusion of propofol 3~6μg/mL, those in group I received inhalation anesthesia with isoflurane 1% ~2%. IL-4, IL-10 and IL-13 were recorded before anesthesia, 0h, 24h, and 48h after operation. Results The serum levels of IL-4, IL-10 and IL-13 were significantly increased at 24h and 48h after operation compared with those before anesthesia in both groups (all P<0.05). The serum levels of IL-4, IL-10 and IL-13 were significantly higher in group P than those in group I at 24h and 48h after operation (all P<0.05). Conclusion The effect of propofol was better than sevoflurane in inhibiting inflammatory reaction in patients with intracranial neoplasms.

Key words: Propofol, isoflurane, intracranial neoplasms, IL-4, IL-10, IL-13