Abstract: Objective The present study attempts to investigate the correlation between the prognosis and the lactate clearance rate in patients with acute severe alcoholic intoxication. Methods Eighty patients suffering from acute severe alcoholic intoxication with initial serum lactate levels after admission to ICU greater than 2.0 mmol/L underwent detection of serum lactate six hours later to calculate the lactate clearance. The APACHE II score and mortality were recorded. The eighty patients fell under survival group (n=76) and death group (n=4), or high lactate clearance rate group (n=68) and low lactate clearance rate group (n=12). The correlation of lactate clearance rate with prognosis was analyzed. Results After the experiment no significant differences in APACHE II score and the initial blood concentration of lactate were found (P＞0.05）. The lactate clearance rate of the survival group was (17.24±8.08)%, which was significantly higher than that of the death group [(0.85±4.45)%, P ＜0.01]. The mortality of the high lactate clearance rate group was 1.47%, which was significantly lower than that of the low lactate clearance rate group (25%, P ＜0.001). Conclusion The lactate clearance rate can be used for early evaluation of the prognosis of the patient with acute severe alcoholic intoxication.

Key words: Acute alcoholic intoxication, Lactate clearance rate, Prognosis