Abstract: [Abstract] Objective:To investigate the effect of high sensitivity C reactive protein(hsCRP) and matrix metalloproteinase 9(MMP-9) on the patients with unstable angina pectoris treated with Atorvastatin. Methods:106 patients with UA were divided into 2 groups,50 patients in the treatment group were treated with Atorvastatin 40mg every day for therthy days,in addition to the conventional therapy. 56 patients in the control group were treated with the conventional therapy.The detection was performed to test the hsCRP and MMP-9 in two groups.Results:① Two groups before treatment do not have difference on total cholesterol(TC),low density lipoprotein- cholesterol(LDL-C),high density lipoprotein- cholesterol(HDL-C).② The treatment group after treatment have a significant difference on TC，LDL-C，HDL-C（P<0.05）.③ To compare 2 groups before treatment and the control group after treatment, hsCRP and MMP-9 have no difference.④ HsCRP and MMP-9 in the treatment group after treatment decreased significantly（P<0.05，P<0.01）.Conclusion: HsCRP and MMP-9 in patients with unstable angina pectoris treated with Atorvastatin have a significant decrease.The data suggested that Atorvastatin can inhibite inflammation,stable plaque and prevent fracture of plaque in addition to regulate lipid.

Key words: Atorvastatin, unstable angina pectoris, high sensitivity C reactive protein, matrix metalloproteinase 9