Abstract:

[Abstract] Objective  To analyze interrelation between anti-Müllerian hormone (AMH) levels and body weight，hormone status and metabolic rate in women with polycystic ovary syndrome (PCOS). Methods  Sixty women (30 normal weight, PCOS 1 group and 30 overweight, PCOS 2 group) diagnosed as PCOS were enrolled and 30 healthy women (15 normal weight and 15 overweight non-PCOS) were as control group．The body weight and height were measured and body mass index(BMI) was calculated. The serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, testosterone, adrenal medullary hormone (AMH), androgens, fasting glucose and fasting insulin were detected, and the homeostasis model of assessment-insulin resistance (HOMA-IR) were caculated and compared between four groups. Results  The levels of AMH, LH, LH/FSH, testosterone, fasting insulin and HOMA-IR were higher in PCOS group than those of control group. There was no significant difference in AMH level between PCOS 1 and PCOS 2 groups. The levels of LH and LH/FSH were lower in PCOS 1 group than those of PCOS 2 group. The levels of fasting insulin and HOMA-IR were higher in PCOS 1 group than those of PCOS 2 group. There were no correlations in AMH and BMI levels in PCOS group. There were positive correlations in AMH and testosterone, fasting glucose and fasting insulin and HOMA-IR in PCOS 1 group，but a negative correlation between estradiol and FSH. A significant positive correlation was found between LH, LH/FSH, testosterone and AMH in PCOS 2 group (P < 0.05). Conclusion  There is a significant increase in plasma AMH in patients with PCOS. The plasma AMH level is not associated with BMI, which may have correlation with hormone imbalance and metabolic disorders.

Key words: polycystic ovary syndrome, anti-Müllerian hormone, hyperandrogenism, insulin resistance