Abstract:

[Abstract] Objective  To observe the clinical effects and changes of serum activity of platelet activating factor (PAF) of mild hypothermia therapeutic (MHT) in patients with massive cerebral infarction, and the mechanisms thereof. Methods  Fifty patients with acute massive cerebral infarction diagnosed within 24 hours were randomly divided into hypothermia therapy group and conventional treatment group. The hypothermia therapy group accepted conventional treatment and hypothermia therapy for 48 hours. The neural function deficiency scores and the serum activity of PAF were compared before treatment and 48 hours after treatment. The U.S. National Institutes of Health Stroke Scale (NIHSS) was used to measure the neural function deficiency. Enzyme linked immunosorbent assay was used to detect the serum activity of PAF. Results  After 48- hour treatment，there were significant differences in the PAF activity and NIHSS scores between hypothermia group and conventional treatment group (P﹤ 0.05). Conclusion  The local mild therapeutic hypothermia can obviously improve the neurological function in patients with acute massive cerebral infarction, which may be involved in the decreased activity of serum PAF.

Key words: Hypothermia, Massive cerebral infarction, Platelet Activating Factor, Neural Function Deficiency Scores.