Abstract:

[Abstract] Objective  To investigate the relationship between serum uric acid and hypertension, and to evaluate the effects of interaction between serum uric acid and other risk factors on hypertension. Methods  The total of 3 318 permanent residents in Tianjin Dagang oilfield were included in this study. All subjects were divided into four groups according to the serum uric acid quartiles. The related factors such as smoking, drinking and family history were investigated. Levels of blood pressure, body mass index (BMI), fasting plasma glucose (FPG), lipid and uric acid were detected and analyzed. Results  The levels of age, blood pressure, BMI, FPG, serum total cholesterol, triacylglycerol and low density lipoprotein cholesterol (LDL-C) were increased with the increase in the level of serum uric acid, but the level of high density lipoprotein cholesterol (HDL-C) was decreased with the increase in the level of uric acid. After adjustment for relevant factors, OR values of hypertension increased with the elevated uric acid levels. The effect of interaction between levels of uric acid and LDL-C was significantly higher in subjects with high levels of LDL-C (P＝0.01). Conclusion  The elevated serum uric acid level was associated with hypertension, which was affected by the interaction between serum uric acid and LDL-C.

Key words: uric acid hypertension blood glucosecholesterol cholesterol, HDL cholesterol, LDLtriglyceridestransactional analysis, LDL