Abstract: Abstract    Objective   To explore the clinical outcomes of hybrid single utility port video-assisted thoracoscopic surgery (VATS) lobectomy for patients with early-stage lung cancer. Methods    From December 2010 to June 2012, 170 surgery patients with early-stage lung cancer were collected and divided into the experimental group and the control group, the experimental group was undergone hybrid single utility port VATS lobectomy (95cases) and the control group was undergone simplemini-incision lobectomy (75cases). The perioperative indicators and the serum levels of humoral immunity were compared between the two groups. Results     There were statistical differences in incision length (4.68±0.24) cm vs. (10.14±1.54) cm, intraoperative blood lose (173.16±31.56) ml vs. (205.93±39.35) ml, numeric pain intensity scale (5.00±1.06) vs. (6.11±1.23), postoperative inpatient days (9.84±0.92) d vs. (12.07±1.46) d between the two groups (P﹤0.05). There were no statistical differences in operation time (140.40±28.25) min vs. (134.53±31.11) min, lymph node dissection number (11.43±1.74) vs. (11.12±1.55), and incidence of serious postoperative complications (13.7％ vs. 24％) between the two groups. The serum levels of C-reactive protein was significantly lower at 1day, 6 day after operation in the experimental group than those of the control group (P﹤0.05). There were statistical differences in the humoral immunity factors，include IgG, IgA, IgM, at 1day, 6 day after operation between the two groups（P﹤0.05）. Conclusions     Hybrid single utility port VATS Lobectomy is safe and reliable for patients with early-stage lung cancer, which is less injury and better immunity recovery than simplemini-incision lobectomy.

Key words: Single utility port, Video-assisted thoracic surgery, Lobectomy, Lung cancer, C-reactive protein, Immunologic function.