Predictive value of acute phase proteins SAA and CRP in non-response to intravenous immunoglobulin in Kawasaki disease

doi:10.11958/20221011

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R725.41

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References 16

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组别	n	年龄（月）	性别（男/女）	体质量（kg）	IVIG前发热时间（d）	不完全性KD	WBC（×10⁹/L）
IVIG应答组	317	23（12，36）	199/118	12.3（10.0，15.0）	6（5，7）	23（7.3）	14.27（11.18，17.81）
IVIG无应答组	41	24（10，36）	28/13	12.0（9.5，14.5）	5（5，6）	5（12.2）	15.49（12.58，19.08）
Z或χ²		0.345	0.476	0.872	2.906^＊＊	0.639	1.797

组别	n	年龄（月）	性别（男/女）	体质量（kg）	IVIG前发热时间（d）	不完全性KD	WBC（×10⁹/L）
IVIG应答组	317	23（12，36）	199/118	12.3（10.0，15.0）	6（5，7）	23（7.3）	14.27（11.18，17.81）
IVIG无应答组	41	24（10，36）	28/13	12.0（9.5，14.5）	5（5，6）	5（12.2）	15.49（12.58，19.08）
Z或χ²		0.345	0.476	0.872	2.906^＊＊	0.639	1.797

变量	β	SE	Wald χ²	P	OR（95%CI）
CRP	0.008	0.003	5.502	0.019	1.008（1.001~1.015）
SAA	0.002	0.001	8.467	0.004	1.002（1.001~1.003）
TBIL	0.029	0.011	7.657	0.006	1.030（1.009~1.051）
血清钠	-0.149	0.063	5.555	0.018	0.862（0.762~0.975）
LYM	-0.311	0.131	5.639	0.018	0.733（0.567~0.947）
IVIG前发热时间	-0.374	0.150	6.249	0.012	0.688（0.513~0.922）
常数项	19.393	8.530	5.169	0.023	2.644×10⁸

变量	β	SE	Wald χ²	P	OR（95%CI）
CRP	0.008	0.003	5.502	0.019	1.008（1.001~1.015）
SAA	0.002	0.001	8.467	0.004	1.002（1.001~1.003）
TBIL	0.029	0.011	7.657	0.006	1.030（1.009~1.051）
血清钠	-0.149	0.063	5.555	0.018	0.862（0.762~0.975）
LYM	-0.311	0.131	5.639	0.018	0.733（0.567~0.947）
IVIG前发热时间	-0.374	0.150	6.249	0.012	0.688（0.513~0.922）
常数项	19.393	8.530	5.169	0.023	2.644×10⁸

指标	敏感度（%）	特异度（%）	截断值	AUC（95%CI）	约登指数
SAA	73.2	59.3	252.45 mg/L	0.681（0.597~0.764）	0.325
CRP	73.2	65.0	82.80 mg/L	0.703（0.626~0.779）	0.382
SAA+CRP	73.2	69.1	-	0.761（0.690~0.832）	0.423

Predictive value of acute phase proteins SAA and CRP in non-response to intravenous immunoglobulin in Kawasaki disease

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