Abstract: [Abstract]   Objective To investigate the effects of Sitagliptin on vascular endothelial function in in Type 2 Diabetes. Methods   45 patients with Type 2 Diabetes Controlled With combination therapy with insulin or other oral hypoglycaemic agents were run-in to the addition of once-daily sitagliptin 100 mg over a 12-week study period. Before and after the treatment o f 16 weeks, The flow-mediated dilation (FMD), fasting plasma glucose(FPG), 2-h postmeal glucose (2hPG), C-peptide, HbAlc and Lipids were measured. Results   The FMD was significantly increased after treatment (p < 0.001). At 12 weeks, the addition of sitagliptin significantly reduced HbA1c(p < 0.05), fasting plasma glucose and 2-h postmeal glucose(p < 0.001). The plasma C-peptide levels significantly increased(p < 0.05), Whereas The change in BMI and lipids were not significantly different(p＞0.05).There was two hypoglycaemic events during the treatment. There was no severe adverse. Conclusion     sitagliptin can improve the endothelial function in Type 2 Diabetes.For patients with Type 2 Diabetes Inadequately Controlled With combination therapy with insulin or other oral hypoglycaemic agents, sitagliptin improved glycaemic control and was generally well tolerated in patients with type 2 diabetes.Without the significant change in body weight.

Key words: diabetes mellitus, type 2, Ultrasonography, Doppler, color, sitagliptin, 彩色